Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog

Background: The major triterpene glycoside of the sea cucumber Psolus patagonicus and its desulfated analog were tested for their antiproliferative, cytotoxic and hemolytic activities, and their effect on NF-κB activation. Methods: The antiproliferative action of glycosides 1 and 2 were determined o...

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Detalles Bibliográficos
Autores principales: Careaga Quiroga, Valeria P., Bueno, Carlos Alberto, Alche, Laura Edith, Maier, Marta Silvia
Publicado: 2009
Materias:
Antiproliferation
Cytotoxicity
Nuclear factor-kappa B
Psolus patagonicus
Sea cucumber
Triterpene glycosides
aglycone
antineoplastic agent
glycoside
hydroxyl group
I kappa B alpha
immunoglobulin enhancer binding protein
patagonicoside a
triterpene derivative
tumor necrosis factor alpha
unclassified drug
animal cell
article
cancer inhibition
cell proliferation
cell viability
chronic inflammation
controlled study
disease association
drug activity
drug cytotoxicity
drug effect
drug isolation
drug mechanism
drug screening
hemolysis
human
human cell
IC 50
immunofluorescence
mouse
nonhuman
priority journal
protein degradation
sea cucumber
staining
structure activity relation
tumor cell line
Western blotting
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v55_n1_p60_Careaga
http://hdl.handle.net/20.500.12110/paper_00093157_v55_n1_p60_Careaga
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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