Neuroprotective action of synthetic steroids with oxygen bridge. Activity on GABAA receptor

Allopregnanolone (A) and pregnanolone (P) are able to modify neural activities acting through the GABAA receptor complex. This capacity makes them useful as anticonvulsant, anxiolytic, or anti-stress compounds. In this study, the performance of seven synthetic steroids (SS) analogous of A or P conta...

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Autores principales:	Rey, Mariana, Alvarez, Lautaro Damián, Ghini, Alberto Antonio, Veleiro, Adriana Silvia, Burton, Gerardo, Coirini, Héctor
Publicado:	2013
Materias:	3β-HSD Cerebellum Hippocampus Hypothalamus Hypoxia Neurosteroids 3alpha hydroxy 11alpha,19 epoxypregn 4 ene 20 one 3alpha hydroxy 1alpha,11alpha epoxy 5alpha pregnan 20 one 3alpha hydroxy 1alpha,11alpha epoxypregn 4 ene 20 one 3alpha hydroxy 1beta,11alpha epoxy 5alpha pregnan 20 one 3alpha hydroxy 2alpha,19 epoxy 5alpha pregnan 20 one 3alpha hydroxy 4alpha,19 epoxy 5alpha pregnan 20 one 3alpha hydroxy 5alpha pregnan 20 one 3alpha hydroxy 6,19 epoxypregn 4 ene 20 one 4 aminobutyric acid A receptor eltanolone flunitrazepam glial fibrillary acidic protein muscimol steroid unclassified drug animal experiment animal tissue article astrocytosis binding affinity binding site brain cortex brain hypoxia brain region cerebellum controlled study drug efficacy drug mechanism drug receptor binding drug response drug structure enzyme activity hippocampus hypoxia ligand binding male mouse neurofilament neuroprotection nonhuman priority journal rat Animals Dose-Response Relationship, Drug Male Neuroprotective Agents Organ Culture Techniques Oxygen Protein Binding Rats Rats, Sprague-Dawley Receptors, GABA-A Steroids
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144886_v249_n_p49_Rey http://hdl.handle.net/20.500.12110/paper_00144886_v249_n_p49_Rey
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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