Effect of SOM230 (Pasireotide) on corticotropic cells: Action in dogs with Cushing's disease

SOM230 (pasireotide) is a multiligand somatostatin (SRIF) analog able to bind to somatostatin receptor (SSTR) subtypes 1, 2, 3 and 5, and trigger antisecretory and antiproliferative signaling cascades. Canines have become in vivo models to test the pharmacological treatment of corticotropinomas beca...

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Detalles Bibliográficos
Publicado: 2011
Materias:
Corticotropes
Cushing's disease
Pituitary adenoma
SOM231
corticotropin
creatinine
hydrocortisone
pasireotide
proopiomelanocortin
somatostatin receptor 2
somatostatin receptor 5
ACTH secreting adenoma
ACTH secreting cell
animal cell
animal experiment
animal model
article
controlled study
Cushing disease
dog
drug mechanism
drug receptor binding
female
hormone synthesis
male
nonhuman
priority journal
protein expression
tumor growth
tumor volume
Adrenocorticotropic Hormone
Alanine Transaminase
Alkaline Phosphatase
alpha-MSH
Animals
Aspartate Aminotransferases
Blood Glucose
Cell Line, Tumor
Cholesterol
Corticotrophs
Creatinine
Dogs
Female
Hydrocortisone
Liver Function Tests
Magnetic Resonance Imaging
Male
Pituitary ACTH Hypersecretion
Somatostatin
Triglycerides
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v94_n2_p124_Castillo
http://hdl.handle.net/20.500.12110/paper_00283835_v94_n2_p124_Castillo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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