Biosynthesis of withanolides in Acnistus breviflorus: biogenetic relationships among the main withanolides
To excised leaves and 15-day-old seedlings of Acnistus breviflorus sodium [1-14C]acetate, [2-14C]mevalonolactone and [14C-methyl]methionine were administered in separate experiments. From the absolute incorporation values of withaferin A (1), jaborosalactone A (2) and jaborosalactone D (3) isolated...
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| Autores principales: | , , |
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1985
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v24_n11_p2573_Veleiro http://hdl.handle.net/20.500.12110/paper_00319422_v24_n11_p2573_Veleiro |
| Aporte de: |
| Sumario: | To excised leaves and 15-day-old seedlings of Acnistus breviflorus sodium [1-14C]acetate, [2-14C]mevalonolactone and [14C-methyl]methionine were administered in separate experiments. From the absolute incorporation values of withaferin A (1), jaborosalactone A (2) and jaborosalactone D (3) isolated at different times after administration of the tracers, it was deduced that compound 2 is a precursor of both 1 and 3 and that the withanolides are later biodegraded to unknown products. Inoculation of [14C]jaborosalactone A confirmed its transformation into 1 and 3. © 1985. |
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