Multivalent sialylation of β-thio-glycoclusters by Trypanosoma cruzi trans sialidase and analysis by high performance anion exchange chromatography

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The synthesis of multivalent sialylated glycoclusters is herein addressed by a chemoenzymatic approach using the trans-sialidase of Trypanosoma cruzi (TcTS). Multivalent β-thio-galactopyranosides and β-thio-lactosides were used as acceptor substrates and 3′-sialyllactose as the sialic acid donor. Hi...

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Detalles Bibliográficos
Autores principales: Cagnoni, Alejandro J., Kovensky, José Eduardo, Muchnik de Lederkremer, Rosa María, Uhrig, María Laura
Publicado: 2016
Materias:
Enzymatic sialylation
HPAEC
MALDI-TOF
Multivalent glycoclusters
Sialic acid
T. cruzi trans-sialidase
β-galactopyranosides
beta thio glycocluster
carbohydrate derivative
glycan
n acetyllactosamine
sialic acid derivative
sialidase
unclassified drug
glycoprotein
lactose
N-acetylneuraminoyllactose
protozoal protein
thioglycoside
trans-sialidase
analytic method
anion exchange chromatography
Article
catalysis
chemical structure
enzyme activity
high performance anion exchange chromatography
matrix-assisted laser desorption-ionization mass spectrometry
nonhuman
priority journal
sialylation
Trypanosoma cruzi
analogs and derivatives
chemistry
enzymology
high performance liquid chromatography
Chromatography, High Pressure Liquid
Glycoproteins
Lactose
Neuraminidase
Protozoan Proteins
Sialic Acids
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Thiogalactosides
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02820080_v33_n5_p809_AgustA­
http://hdl.handle.net/20.500.12110/paper_02820080_v33_n5_p809_AgustA­
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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