Simple stereocontrolled synthesis of methyl 2-deoxy-d-£/mffl(?-hexopyranosid-4-uloses, thromboxane B2 (txb2) precursors, from d-galactose
The stereospecific synthesis of methyl 3-0-benzoyl-6-0-(tert-butyldiphenylsilyl)-2-deoxy-a-D-e/j//iro-hexopyranosid-4-ulose (5) - a Thromboxane B2 (TXB2) precursor - starting from D-galactose is described. Facile and established methods including selective benzoylation, oxidation-elimination and a s...
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1995
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_07328303_v14_n4-5_p525_Moradei http://hdl.handle.net/20.500.12110/paper_07328303_v14_n4-5_p525_Moradei |
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| Sumario: | The stereospecific synthesis of methyl 3-0-benzoyl-6-0-(tert-butyldiphenylsilyl)-2-deoxy-a-D-e/j//iro-hexopyranosid-4-ulose (5) - a Thromboxane B2 (TXB2) precursor - starting from D-galactose is described. Facile and established methods including selective benzoylation, oxidation-elimination and a stereocontrolled hydrogenation (Pd /charcoal) were employed effectively. © 1995, Taylor & Francis Group, LLC. All rights reserved. |
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