Escherichia coli β-galactosidase inhibitors through modifications at the aglyconic moiety: Experimental evidence of conformational distortion in the molecular recognition process
Herein, we describe the use of thioglycosides as glycosidase inhibitors by employing novel modifications at the reducing end of these glycomimetics. The inhibitors display a basic galactopyranosyl unit (1→4)-bonded to a 3-deoxy-4-thiopentopyranose moiety. The molecular basis of the observed inhibiti...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09476539_v19_n13_p4262_Calle http://hdl.handle.net/20.500.12110/paper_09476539_v19_n13_p4262_Calle |
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