An antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains herpes simplex virus type 1 propagation

Meliacine (MA), an antiviral principle isolated from leaves of Melia azedarach L., exhibits potent antiviral activity against herpes simplex virus type 1 (HSV-1) by inhibiting specific infected-cell polypeptides (ICPs) produced late in infection. Some of these are involved in DNA synthesis and in th...

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Detalles Bibliográficos
Autores principales:	Alche, Laura Edith, Barquero, Andrea Alejandra, Coto, Celia Esther
Publicado:	2002
Materias:	Antiviral Herpes simplex virus type 1 Melia azedarach L. Meliacine antivirus agent beta galactosidase meliacine polypeptide unclassified drug virus DNA animal cell antiviral activity aqueous solution article controlled study cytoplasm cytoplasm vesicle DNA cleavage DNA packaging DNA synthesis drug mechanism drug synthesis enzyme activity Herpes simplex virus 1 medicinal plant melia azedarach molecular weight nonhuman plant leaf time Vero cell virus envelope virus inhibition virus nucleocapsid virus particle virus replication Animals Antiviral Agents Cell Transformation, Viral Cercopithecus aethiops DNA, Viral Herpesvirus 1, Human Meliaceae Plant Extracts Plant Leaves Vero Cells Viral Proteins Virus Replication Human herpesvirus 1 Melia azedarach Simplexvirus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v16_n4_p348_Alche http://hdl.handle.net/20.500.12110/paper_0951418X_v16_n4_p348_Alche
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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