ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum

Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the is...

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Guardado en:
Detalles Bibliográficos
Publicado: 2002
Materias:
Brine shrimp test
Cytotoxicity
Elaeoselinum foetidum
Ent-kaur-16-en-19-oic acid
KB cells
chloroform
colchicine
diterpenoid
DNA
Elaeoselinum foetidum extract
kaurenoic acid
methyl green
plant extract
sodium chloride
unclassified drug
Apiales
article
bioassay
cell strain KB
chromatography
controlled study
drug cytotoxicity
drug DNA interaction
drug exposure
drug isolation
drug potency
drug structure
fractionation
high performance liquid chromatography
higher plant
human
human cell
IC 50
LC 50
nonhuman
shrimp
structure analysis
toxicity testing
Animals
Antineoplastic Agents, Phytogenic
Apiaceae
Artemia
Carcinoma, Squamous Cell
Cytotoxins
Diterpenes
Humans
Inhibitory Concentration 50
KB Cells
Lethal Dose 50
Molecular Structure
Anostraca
Decapoda (Crustacea)
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v16_n4_p387_Mongelli
http://hdl.handle.net/20.500.12110/paper_0951418X_v16_n4_p387_Mongelli
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent-kaur-16-en-19-oic acid. This compound was potent against the brine shrimp (LC50 = 4.8 μg/mL) and KB cells (IC50 = 1.6 μg/mL). Copyright © 2002 John Wiley & Sons, Ltd.

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