OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis

Background: Galectin-1 (Gal1), a carbohydrate-binding protein is implicated in cancer cell proliferation, invasion and tumour angiogenesis. Several Gal1-targeting compounds have recently emerged. OTX008 is a calixarene derivative designed to bind the Gal1 amphipathic β-sheet conformation. Our study...

Descripción completa

Guardado en:

Detalles Bibliográficos
Publicado:	2014
Materias:	Anginex Calixarene compounds Cell invasion Cell proliferation Galectin-1 Neuropilin-1
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598049_v_n_p_AstorguesXerri http://hdl.handle.net/20.500.12110/paper_09598049_v_n_p_AstorguesXerri
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis
por: Astorgues-Xerri, L., et al.

OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis
Publicado: (2014)

OTX008, a selective small-molecule inhibitor of galectin-1, downregulates cancer cell proliferation, invasion and tumour angiogenesis
por: Astorgues-Xerri, L.

Glycans and galectins in prostate cancer biology, angiogenesis and metastasis
Publicado: (2014)

Glycans and galectins in prostate cancer biology, angiogenesis and metastasis
por: Compagno, D., et al.

Galectins: Multitask signaling molecules linking fibroblast, endothelial and immune cell programs in the tumor microenvironment
Publicado: (2018)

Galectins: Multitask signaling molecules linking fibroblast, endothelial and immune cell programs in the tumor microenvironment
por: Elola, M.T., et al.

Vascular galectins: Regulators of tumor progression and targets for cancer therapy
Publicado: (2013)

Vascular galectins: Regulators of tumor progression and targets for cancer therapy
por: Thijssen, V.L., et al.

Introduction to special issue: Galectins go with the flow
Publicado: (2014)

Introduction to special issue: Galectins go with the flow
por: Rabinovich, G.A., et al.

'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
por: Blidner, Ada G.
Publicado: (2013)

'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
por: Blidner, A.G., et al.
Publicado: (2013)

'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
por: Blidner, A.G., et al.

'Sweetening' Pregnancy: Galectins at the Fetomaternal Interface
por: Blidner, A.G., et al.
Publicado: (2013)

Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity
Publicado: (2014)

Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity
por: Dimitroff, C.J., et al.

Galectins and microenvironmental niches during hematopoiesis
Publicado: (2011)

Galectins and microenvironmental niches during hematopoiesis
por: Rabinovich, G.A., et al.

Galectins in hematological malignancies
Publicado: (2013)

Galectins in hematological malignancies
por: Giordano, M., et al.

Galectins: Key players at the frontiers of innate and adaptive immunity
Publicado: (2018)

Galectins: Key players at the frontiers of innate and adaptive immunity
por: Martínez Allo, V.C., et al.

Modulation of endothelial cell migration and angiogenesis: A novel function for the "tandem-repeat" lectin galectin-8
por: Troncoso, María Fernanda, et al.
Publicado: (2011)

Modulation of endothelial cell migration and angiogenesis: A novel function for the "tandem-repeat" lectin galectin-8
por: Cárdenas Delgado, V.M., et al.

Galectin-8: A matricellular lectin with key roles in angiogenesis
por: Troncoso, María Fernanda, et al.
Publicado: (2014)

Galectin-8: A matricellular lectin with key roles in angiogenesis
por: Troncoso, M.F., et al.

Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities
Publicado: (2018)

Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities
por: Seropian, I.M., et al.

Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
Publicado: (2018)

Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
por: Sundblad, V., et al.

Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
Publicado: (2017)

Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
por: Méndez-Huergo, S.P., et al.

Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment
por: Croci Russo, Diego Omar
Publicado: (2014)

Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment
por: Croci, D.O., et al.

Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer
Publicado: (2008)

Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer
por: Salatino, M., et al.

Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity
Publicado: (2018)

Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity
por: Mendez-Huergo, S.P., et al.

Glycosylation-dependent galectin–receptor interactions promote Chlamydia trachomatis infection
Publicado: (2018)