Carbohydrate PEGylation, an approach to improve pharmacological potency

Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Giorgi, María Eugenia, Agustí, Rosalía, Muchnik de Lederkremer, Rosa María
Publicado: 2014
Materias:
Bioavailability
Carbohydrates
Conjugates
Glycopegylation
Multivalent glycosystems
Multivalent PEGylation
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18605397_v10_n_p1433_Giorgi
http://hdl.handle.net/20.500.12110/paper_18605397_v10_n_p1433_Giorgi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_18605397_v10_n_p1433_Giorgi
record_format dspace
spelling paper:paper_18605397_v10_n_p1433_Giorgi2023-06-08T16:29:26Z Carbohydrate PEGylation, an approach to improve pharmacological potency Giorgi, María Eugenia Agustí, Rosalía Muchnik de Lederkremer, Rosa María Bioavailability Carbohydrates Conjugates Glycopegylation Multivalent glycosystems Multivalent PEGylation Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of the attached protein while yielding a more defined product. Thus, glycoPEGylation was successfully applied to the introduction of a PEGylated sialic acid to a preexisting or enzymatically linked glycan in a protein. Carbohydrates are now recognized as playing an important role in host-pathogen interactions in protozoal, bacterial and viral infections and are consequently candidates for chemotherapy. The short in vivo half-life of low molecular weight glycans hampered their use but methods for the covalent attachment of PEG have been less exploited. In this review, information on the preparation and application of PEG-carbohydrates, in particular multiarm PEGylation, is presented. © 2014 Giorgi et al. Fil:Giorgi, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Agusti, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De Lederkremer, R.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18605397_v10_n_p1433_Giorgi http://hdl.handle.net/20.500.12110/paper_18605397_v10_n_p1433_Giorgi
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Bioavailability
Carbohydrates
Conjugates
Glycopegylation
Multivalent glycosystems
Multivalent PEGylation
spellingShingle Bioavailability
Carbohydrates
Conjugates
Glycopegylation
Multivalent glycosystems
Multivalent PEGylation
Giorgi, María Eugenia
Agustí, Rosalía
Muchnik de Lederkremer, Rosa María
Carbohydrate PEGylation, an approach to improve pharmacological potency
topic_facet Bioavailability
Carbohydrates
Conjugates
Glycopegylation
Multivalent glycosystems
Multivalent PEGylation
description Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of the attached protein while yielding a more defined product. Thus, glycoPEGylation was successfully applied to the introduction of a PEGylated sialic acid to a preexisting or enzymatically linked glycan in a protein. Carbohydrates are now recognized as playing an important role in host-pathogen interactions in protozoal, bacterial and viral infections and are consequently candidates for chemotherapy. The short in vivo half-life of low molecular weight glycans hampered their use but methods for the covalent attachment of PEG have been less exploited. In this review, information on the preparation and application of PEG-carbohydrates, in particular multiarm PEGylation, is presented. © 2014 Giorgi et al.
author Giorgi, María Eugenia
Agustí, Rosalía
Muchnik de Lederkremer, Rosa María
author_facet Giorgi, María Eugenia
Agustí, Rosalía
Muchnik de Lederkremer, Rosa María
author_sort Giorgi, María Eugenia
title Carbohydrate PEGylation, an approach to improve pharmacological potency
title_short Carbohydrate PEGylation, an approach to improve pharmacological potency
title_full Carbohydrate PEGylation, an approach to improve pharmacological potency
title_fullStr Carbohydrate PEGylation, an approach to improve pharmacological potency
title_full_unstemmed Carbohydrate PEGylation, an approach to improve pharmacological potency
title_sort carbohydrate pegylation, an approach to improve pharmacological potency
publishDate 2014
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18605397_v10_n_p1433_Giorgi
http://hdl.handle.net/20.500.12110/paper_18605397_v10_n_p1433_Giorgi
work_keys_str_mv AT giorgimariaeugenia carbohydratepegylationanapproachtoimprovepharmacologicalpotency
AT agustirosalia carbohydratepegylationanapproachtoimprovepharmacologicalpotency
AT muchnikdelederkremerrosamaria carbohydratepegylationanapproachtoimprovepharmacologicalpotency
_version_ 1768545621643362304

Ejemplares similares