Compound a, a dissociated glucocorticoid receptor modulator, inhibits t-bet (th1) and induces gata-3 (th2) activity in immune cells

Background: Compound A (CpdA) is a dissociating non-steroidal glucocorticoid receptor (GR) ligand which has anti-inflammatory properties exerted by down-modulating proinflammatory gene expression. By favouring GR monomer formation, CpdA does not enhance glucocorticoid (GC) response element-driven ge...

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Detalles Bibliográficos
Autores principales:	Liberman, Ana, Castro, Carla Noemí, Druker, Jimena Paola
Publicado:	2012
Materias:	compound A dexamethasone gamma interferon glucocorticoid receptor interleukin 5 mifepristone transcription factor GATA 3 unclassified drug 2 (4 acetoxyphenyl) 2 chloro N methyl ethylammonium chloride 2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride aziridine derivative Gata3 protein, mouse quaternary ammonium derivative T box transcription factor T box transcription factor TBX21 T-box transcription factor TBX21 animal cell article cell differentiation controlled study cytokine production dimerization enzyme linked immunosorbent assay gene expression immune response immunocompetent cell ligand binding mouse nonhuman protein expression protein phosphorylation reporter gene spleen cell Th1 cell Th2 cell animal Bagg albino mouse biosynthesis drug antagonism drug effect drug potentiation immunology spleen T lymphocyte Th1 Th2 balance Murinae Animals Aziridines GATA3 Transcription Factor Interferon-gamma Mice Mice, Inbred BALB C Mifepristone Quaternary Ammonium Compounds Receptors, Glucocorticoid Spleen T-Box Domain Proteins T-Lymphocytes Th1 Cells Th1-Th2 Balance Th2 Cells
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v7_n4_p_Liberman http://hdl.handle.net/20.500.12110/paper_19326203_v7_n4_p_Liberman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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