Internalization of locked nucleic acids/DNA hybrid oligomers into escherichia coli

Delivery inside the cells is essential for practical application of antisense technologies. The hybrid locked nucleic acid (LNA)/DNA CAAGTACTGTTCCACCA (LNA residues are underlined) was labeled by conjugation to Alexa Fluor 488 (fLNA/DNA) and tested to determine its ability to penetrate Escherichia c...

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Detalles Bibliográficos
Publicado:	2012
Materias:	Drug discovery Drug resistance Gene therapy Microbiology Nucleic acids alexa fluor 488 locked nucleic acid oligomer unclassified drug antisense therapy article bacterial cell cell culture confocal microscopy conjugation controlled study cytoplasm drug penetration Escherichia coli flow cytometry gene delivery system nonhuman priority journal
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_21647860_v1_n5_p260_Traglia http://hdl.handle.net/20.500.12110/paper_21647860_v1_n5_p260_Traglia
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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