Synthesis of α-D-galactofuranosyl phosphate
D-Galactofuranosyl units (Galf), mainly in the β-configuration, are constituents of infectious microorganisms, such as the Mycobacteria, trypanosomatids like Trypanosoma cruzi and Leishmania, and fungi like Aspergillus fumigatus. Several chemical syntheses of the Galf nucleotide have been reported....
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_97814398_v2_n_p223_Marino http://hdl.handle.net/20.500.12110/paper_97814398_v2_n_p223_Marino |
| Aporte de: |
| Sumario: | D-Galactofuranosyl units (Galf), mainly in the β-configuration, are constituents of infectious microorganisms, such as the Mycobacteria, trypanosomatids like Trypanosoma cruzi and Leishmania, and fungi like Aspergillus fumigatus. Several chemical syntheses of the Galf nucleotide have been reported. Recently, an effective chemoenzymatic procedure for the preparation of UDP-Galf was described in detail. The chemical and enzymatic methods start with α-D-Galf phosphate, prepared for the first time by Lederkremer et al. Starting from α-D-[6-3H]-Galf phosphate, the radioactive nucleotide, useful for metabolic studies, was chemically synthesized. © 2014 by Taylor & Francis Group, LLC. |
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