Homogeneous boron targeting of heterogeneous tumors for boron neutron capture therapy (BNCT): Chemical analyses in the hamster cheek pouch oral cancer model

Objective: BNCT is a tumour cell targeted radiation therapy. Uniform targeting of heterogeneous tumours with therapeutically effective boron carriers would contribute to a therapeutic effect on all tumour cell populations and avoid radioresistant fractions. This remains an unresolved challenge. The...

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Detalles Bibliográficos
Autores principales: Heber, E.M., Trivillin, V.A., Nigg, D.W., Itoiz, M.E., Gonzalez, B.N., Rebagliati, R.J., Batistoni, D., Kreimann, E.L., Schwint, A.E.
Formato: JOUR
Materias:
BNCT
Boron targeting
Hamster cheek pouch
Oral cancer
4 dihydroxyborylphenylalanine
4-dihydroxyborylphenylalanine
7,12 dimethylbenz[a]anthracene
borane derivative
boron derivative
drug derivative
phenylalanine
animal
article
cheek
chemically induced disorder
disease model
hamster
metabolism
methodology
mouth mucosa
mouth tumor
neutron capture therapy
precancer
Syrian hamster
9,10-Dimethyl-1,2-benzanthracene
Animals
Borohydrides
Boron Compounds
Boron Neutron Capture Therapy
Cheek
Cricetinae
Disease Models, Animal
Mesocricetus
Mouth Mucosa
Mouth Neoplasms
Phenylalanine
Precancerous Conditions
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00039969_v51_n10_p922_Heber
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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