Generation of amyloid β protein from a presenilin-1 and βAPP complex

Presenilin-1 (PS1) is a causative gene in early onset familial Alzheimer’s disease (FAD). FAD-linked mutant PS1s significantly increased Aβ40 and Aβ42(43) levels (P < 0.001) and decreased the production of an 11.4 kD (β-stub) and an 8.7 kD (α-stub) carboxyl-terminal fragment of amyloid β precurso...

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Detalles Bibliográficos
Autores principales:	Shizuka-Ikeda, M., Matsubara, E., Ikeda, M., Kanai, M., Tomidokoro, Y., Ikeda, Y., Watanabe, M., Kawarabayashi, T., Harigaya, Y., Okamoto, K., Shoji, M., Maruyama, K., Castao, E.M., St. George-Hyslop, P.
Formato:	JOUR
Materias:	Aβ40 Aβ42(43) Presenilin-1 PS1/βAPP complex βAPP γ-secretase 3 [(3 cholamidopropyl)dimethylammonio] 1 propanesulfonic acid amyloid beta protein enzyme inhibitor gamma secretase mutant protein presenilin 1 protein precursor Alzheimer disease amino terminal sequence article carboxy terminal sequence cell line cell lysate pathogenesis pH precipitation priority journal protein analysis protein degradation protein isolation reaction analysis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0006291X_v292_n2_p571_ShizukaIkeda
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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