The influence of the vehicle on the synthesis of porphyrins after topical application of 5-aminolaevulinic acid. Implications in cutaneous photodynamic sensitization

Background The optimal vehicle to ensure adequate penetration of 5-aminolaevulinic acid (ALA) for its use in photodynamic therapy (PDT) of skin lesions has not been determined. Objectives We aimed to study the effects of ALA in various vehicle formulations [saline lotion with and without dimethylsul...

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Detalles Bibliográficos
Autores principales: Casas, A., Fukuda, H., Di Venosa, G., Del C.Batlle, A.M.
Formato: JOUR
Materias:
5-Aminolaevulinic acid
Dimethylsulphoxide
Liposomes
Photodynamic therapy
Porphyrins
Topical application
aminolevulinic acid
dimethyl sulfoxide
drug vehicle
enzyme
liposome
petrolatum
porphobilinogen
porphyrin
animal experiment
animal model
animal tissue
article
controlled study
cream
drug distribution
drug effect
drug formulation
drug mechanism
drug penetration
lotion
male
mouse
nonhuman
photodynamic therapy
photosensitization
priority journal
skin cancer
Adenocarcinoma
Administration, Topical
Aminolevulinic Acid
Animals
Carbon Radioisotopes
Dimethyl Sulfoxide
Drug Carriers
Isotonic Solutions
Male
Mice
Mice, Inbred BALB C
Photochemotherapy
Photosensitizing Agents
Skin
Skin Neoplasms
Sodium Chloride
Solvents
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00070963_v143_n3_p564_Casas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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