Molecular modelling of the interactions of carbamazepine and a nicotinic receptor involved in the autosomal dominant nocturnal frontal lobe epilepsy

1 The normal and a mutant (S248F) human neuronal α4β2 nicotinic receptors, and their interaction with the channel blocker carbamazepine (CBZ) have been modelled. The mutant, responsible for the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), has an enhanced sensitivity to and a slower r...

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Detalles Bibliográficos
Autores principales: Ortells, M.O., Barrantes, G.E.
Formato: JOUR
Materias:
Carbamazepine
Epilepsy
Molecular modelling
Nicotinic receptor
anticonvulsive agent
carbamazepine
functional group
mutant protein
nicotinic receptor
serine
nicotinic receptor alpha4beta2
article
autosomal dominant disorder
binding affinity
calcium transport
dehydration
drug binding site
drug receptor binding
frontal lobe epilepsy
hydrogen bond
molecular model
molecular size
physical chemistry
prediction
priority journal
structure activity relation
chemical structure
chemistry
dominant gene
genetics
human
metabolism
mutation
Anticonvulsants
Epilepsy, Frontal Lobe
Genes, Dominant
Human
Models, Molecular
Mutation
Receptors, Nicotinic
Support, Non-U.S. Gov't
Humans
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00071188_v136_n6_p883_Ortells
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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