Synthesis and antiviral activity of azoles obtained from carbohydrates

Herein we describe the synthesis of 1,2,4-triazolyl-3-thione;1,3,4-oxadiazole, and imidazo[2,1-b]thiazole derivatives from carbohydrates. The antiviral activity of these compounds was tested against Dengue and Junin virus (the etiological agent of Argentine hemorrhagic fever). The 3-(p-bromobenzoyl)...

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Autores principales:	Barradas, J.S., Errea, M.I., D'Accorso, N.B., Sepúlveda, C.S., Talarico, L.B., Damonte, E.B.
Formato:	JOUR
Materias:	1,2,4-Triazolyl-3-thione 1,3,4-Oxadiazole Antiviral activity Carbohydrates Imidazo[2,1-b]thiazole Arsenic compounds Biomolecules Chlorine compounds Concentration (process) Organic compounds Viruses Antiviral activities Etiological agents Isopropylidene Junin virus Thiazole derivatives Vero cells Complexation 1,2 o isopropylidene alpha dextro xylopentadialdo 1,4 furanose(2 bromobenzoyl)hydrazone 1,2 o isopropylidene alpha dextro xylopentadialdo 1,4 furanose(2 chlorobenzoyl)hydrazone 1,2 o isopropylidene alpha dextro xylopentadialdo 1,4 furanose(3 bromobenzoyl)hydrazone 1,2 o isopropylidene alpha dextro xylopentadialdo 1,4 furanose(3 chlorobenzoyl)hydrazone 1,2 o isopropylidene alpha dextro xylopentadialdo 1,4 furanose(4 bromobenzoyl)hydrazone 1,2 o isopropylidene alpha dextro xylopentadialdo 1,4 furanose(4 chlorobenzoyl)hydrazone 1,2,4 triazolyl 3 thione 1,3,4 oxadiazole derivative 2 (1,2 o isopropylidene alpha dextro xylo tetrafuranos 4 yl) 5 (2 bromophenyl) 1,3,4 oxadiazole 2 (1,2 o isopropylidene alpha dextro xylo tetrafuranos 4 yl) 5 (2 chlorophenyl) 1,3,4 oxadiazole 2 (1,2 o isopropylidene alpha dextro xylo tetrafuranos 4 yl) 5 (3 bromophenyl) 1,3,4 oxadiazole 2 (1,2 o isopropylidene alpha dextro xylo tetrafuranos 4 yl) 5 (3 chlorophenyl) 1,3,4 oxadiazole 2 (1,2 o isopropylidene alpha dextro xylo tetrafuranos 4 yl) 5 (4 bromophenyl) 1,3,4 oxadiazole 2 (1,2 o isopropylidene alpha dextro xylo tetrafuranos 4 yl) 5 (4 chlorophenyl) 1,3,4 oxadiazole 3 (4 bromobenzoyl) 5 (1,2 o isopropylidene 3 o methyl alpha dextro xylofuranos 5 ulo 5 yl)imidazo[2,1 b]thiazole 3 (4 bromobenzoyl) 5 (1,2 o isopropylidene 3 o methyl alpha dextro xylofuranos 5 ulos 5 yl)imidazo[2,1 b]thiazole 3 benzoyl 5 (1,2 o isopropylidene 3 o methyl alpha dextro xylofuranos 5 ulo 5 yl)imidazo[2,1-b]thiazole 3,5 di o acetyl 6 deoxy 1,2 isopropylidene 6 [(4 bromobenzohydrazinecarbothionyl)amino]alpha dextro glucofuranose 5 (4 clorophenyl) 4 (1,2 o isopropylidene alpha dextro glucofuranos 6 yl) 1,2,4 triazoline 3 thione 6 bromo 5 deoxy 1,2 o isopropylidene 3 o methyl alpha dextro xylo hexofuranos 5 ulose 6 bromo 6 deoxy 1,2 o isopropylidene 3 o methyl alpha dextro glucofuranose antivirus agent imidazo[2,1 b]thiazole derivative n (5 benzoylthiazol 2 yl) n,n dimethylformamidine n' (5 4 bromobenzoylthiazol 2 yl) n,n dimethylformamidine unclassified drug animal cell antiviral activity article carbon nuclear magnetic resonance Dengue virus drug structure drug synthesis nonhuman priority journal proton nuclear magnetic resonance structure activity relation Vero cell Animals Antiviral Agents Azoles Cercopithecus aethiops Dengue Virus Inhibitory Concentration 50 Toxicity Tests Vero Cells
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00086215_v343_n14_p2468_Barradas
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires