Reciprocal regulation of TREK-1 channels by arachidonic acid and CRH in mouse corticotropes

Arachidonic acid (AA) is generated in the anterior pituitary gland upon stimulation by the ACTH secretagogue, CRH. Using the patch clamp technique, we examined the action of AA on the excitability of single pituitary corticotropes obtained from a transgenic mouse strain that expresses the enhanced g...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lee, A.K., Smart, J.L., Rubinstein, M., Low, M.J., Tse, A.
Formato: JOUR
Materias:
8 (4 chlorophenylthio) cyclic AMP
adenylate cyclase
arachidonic acid
chlorpromazine
corticotropin releasing factor
diphenylbutylpiperidine derivative
enhanced green fluorescent protein
fluoxetine
potassium channel
potassium ion
twik related potassium channel 1
unclassified drug
acidification
ACTH secreting cell
animal cell
article
controlled study
fatty acid metabolism
hyperpolarization
membrane depolarization
mouse
nonhuman
potassium current
priority journal
protein expression
voltage clamp
Animals
Arachidonic Acid
Cells, Cultured
Chlorpromazine
Corticotrophs
Corticotropin-Releasing Hormone
Cyclic AMP
Fluoxetine
Green Fluorescent Proteins
Hydrogen-Ion Concentration
Membrane Potentials
Mice
Mice, Transgenic
Neuroprotective Agents
Patch-Clamp Techniques
Potassium Channels, Tandem Pore Domain
Thionucleotides
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00137227_v152_n5_p1901_Lee
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares