Inhibitory Effect of 1‐β‐d‐Arabinofuranosylcytosine on the Synthesis of Phosphatidyl‐dCMP

The synthesis of phosphatidyl‐dCMP in mouse thymocytes is inhibited by the antineoplastic agent 1‐β‐d‐arabinofuranosyl cytosine (AraCyt)50% inhibition (ID50) being reached at an AraCyt concentration of 0.18 mM. IN the same cells, ID50 for DNA synthesis is 0.03 mM. This inhibition is probably mediate...

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Detalles Bibliográficos
Autores principales: IUJVIDIN, S., FELEDI, C., MEDRANO, E.E., MORDOH, J.
Formato: JOUR
Materias:
cytarabine
deoxyribonuclease
radioisotope
cancer chemotherapy
drug inhibition
in vitro study
mouse
nonhuman
phosphatidyldeoxycytidine phosphate
therapy
thymocyte
thymus
Animal
Cytarabine
Deoxycytidine Monophosphate
Deoxycytosine Nucleotides
In Vitro
Mice
Mice, Inbred BALB C
Support, Non-U.S. Gov't
Thymus Gland
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00142956_v130_n2_p293_IUJVIDIN
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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