IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness

IL-27, a member of the IL-12 family of cytokines, is produced by APCs, and displays pro- and anti-inflammatory effects. How IL-27 affects human NK cells still remains unknown. In this study, we observed that mature DCs secreted IL-27 and that blockade of IL-27R (CD130) reduced the amount of IFN-γ pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ziblat, A., Domaica, C.I., Spallanzani, R.G., Iraolagoitia, X.L.R., Rossi, L.E., Avila, D.E., Torres, N.I., Fuertes, M.B., Zwirner, N.W.
Formato:	JOUR
Materias:	Cytotoxicity IFN-γ IL-18 IL-27 NK cells CD69 antigen Fas antigen Fas ligand fludarabine gamma interferon glycoprotein gp 130 immunoglobulin enhancer binding protein interleukin 10 interleukin 12 interleukin 15 interleukin 17 interleukin 18 interleukin 2 interleukin 2 receptor alpha interleukin 27 interleukin 4 interleukin 6 Janus kinase 2 mammalian target of rapamycin mitogen activated protein kinase kinase 1 mitogen activated protein kinase kinase 2 mitogen activated protein kinase p38 natural cytotoxicity triggering receptor 1 perforin phosphatidylinositol 3 kinase STAT1 protein stress activated protein kinase transcription factor T bet tumor necrosis factor tumor necrosis factor related apoptosis inducing ligand IL27 protein, human IL2RA protein, human IL6ST protein, human interleukin 18 protein, human interleukin derivative lectin leukocyte antigen monoclonal antibody recombinant protein T lymphocyte antigen Article cancer cell line cell maturation cell mediated cytotoxicity cell surface cell viability coculture controlled study cytokine release cytokine response dendritic cell effector cell enzyme linked immunosorbent assay exocytosis flow cytometry HCT116 cell line human human cell lymphocyte function natural killer cell priority journal protein expression protein protein interaction Raji cell line secretory pathway T 47D cell target cell upregulation cell proliferation cell survival cytology cytotoxicity drug effects gene expression regulation genetics immunology primary cell culture signal transduction Antibodies, Monoclonal Antigens, CD Antigens, Differentiation, T-Lymphocyte Cell Proliferation Cell Survival Coculture Techniques Cytokine Receptor gp130 Cytotoxicity, Immunologic Dendritic Cells Gene Expression Regulation HCT116 Cells Humans Interleukin-18 Interleukin-2 Receptor alpha Subunit Interleukins Killer Cells, Natural Lectins, C-Type Primary Cell Culture Recombinant Proteins Signal Transduction
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00142980_v45_n1_p192_Ziblat
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness
por: Ziblat, Andrea, et al.
Publicado: (2015)

Interleukin (IL)-23 stimulates IFN-γ secretion by CD56bright natural killer cells and enhances IL-18-driven dendritic cells activation
Publicado: (2018)

Interleukin (IL)-23 stimulates IFN-γ secretion by CD56bright natural killer cells and enhances IL-18-driven dendritic cells activation
por: Ziblat, A., et al.

Regulatory dendritic cells restrain NK cell IFN-γ production through mechanisms involving NKp46, IL-10, and MHC class I-specific inhibitory receptors
por: Ziblat, Andrea, et al.
Publicado: (2015)

Regulatory dendritic cells restrain NK cell IFN-γ production through mechanisms involving NKp46, IL-10, and MHC class I-specific inhibitory receptors
por: Spallanzani, R.G., et al.

Regulation of NK cell activation and effector functions by the IL-12 family of cytokines: The case of IL-27
por: Ziblat, Andrea
Publicado: (2017)

Regulation of NK cell activation and effector functions by the IL-12 family of cytokines: The case of IL-27
por: Zwirner, N.W., et al.

A laboratory scale device for microencapsulation of genetically engineered cells into alginate beads
por: Finocchiaro, Liliana María Elena, et al.
Publicado: (2002)

A laboratory scale device for microencapsulation of genetically engineered cells into alginate beads
por: Fiszman, G.L., et al.

Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
Publicado: (2016)

Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling
por: Sampson, J.F., et al.

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
por: Croci Russo, Diego Omar
Publicado: (2012)

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
por: Rabinovich, G., et al.

Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses
Publicado: (2017)

Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses
por: Hernández Del Pino, R.E., et al.

Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation
por: Liberman, Ana, et al.
Publicado: (2003)

Cytokine Signaling/Transcription Factor Cross-Talk in T Cell Activation and Th1-Th2 Differentiation
por: Liberman, A.C., et al.

Monocyte-derived dendritic cells loaded with a mixture of apoptotic/ necrotic melanoma cells efficiently cross-present gp100 and MART-1 antigens to specific CD8+ T lymphocytes
por: von Euw, Erika María, et al.
Publicado: (2007)

Monocyte-derived dendritic cells loaded with a mixture of apoptotic/ necrotic melanoma cells efficiently cross-present gp100 and MART-1 antigens to specific CD8+ T lymphocytes
por: von Euw, E.M., et al.
Publicado: (2007)

Monocyte-derived dendritic cells loaded with a mixture of apoptotic/ necrotic melanoma cells efficiently cross-present gp100 and MART-1 antigens to specific CD8+ T lymphocytes
por: von Euw, E.M., et al.

Monocyte-derived dendritic cells loaded with a mixture of apoptotic/ necrotic melanoma cells efficiently cross-present gp100 and MART-1 antigens to specific CD8+ T lymphocytes
por: von Euw, E.M., et al.
Publicado: (2007)

Early effects of insulin-like growth factor-1 in activated human T lymphocytes
Publicado: (2001)

Early effects of insulin-like growth factor-1 in activated human T lymphocytes
por: Brocardo, M.G., et al.

IL17A augments autophagy in Mycobacterium tuberculosis-infected monocytes from patients with active tuberculosis in association with the severity of the disease
por: Amiano, Nicolás Oscar, et al.
Publicado: (2017)

IL17A augments autophagy in Mycobacterium tuberculosis-infected monocytes from patients with active tuberculosis in association with the severity of the disease
por: Tateosian, N.L., et al.

Differential migration and activation profile of monocytes after trophoblast interaction
Publicado: (2014)

Differential migration and activation profile of monocytes after trophoblast interaction
por: Grasso, E., et al.

IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
Publicado: (2009)

IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
por: Pasquinelli, V., et al.

Human Natural Killer Cell Maturation Defect Supports In Vivo CD56bright to CD56dim Lineage Development
por: Domaica, Carolina Inés, et al.
Publicado: (2012)

Human Natural Killer Cell Maturation Defect Supports In Vivo CD56bright to CD56dim Lineage Development
por: Domaica, C.I., et al.
Publicado: (2012)

Human Natural Killer Cell Maturation Defect Supports In Vivo CD56bright to CD56dim Lineage Development
por: Domaica, C.I., et al.

Human Natural Killer Cell Maturation Defect Supports In Vivo CD56bright to CD56dim Lineage Development
por: Domaica, C.I., et al.
Publicado: (2012)

The Th1 and Th2 cytokines IFN-γ and IL-4 antagonize the inhibition of monocyte IL-1 receptor antagonist by glucocorticoids: Involvement of IL-1
Publicado: (1998)

The Th1 and Th2 cytokines IFN-γ and IL-4 antagonize the inhibition of monocyte IL-1 receptor antagonist by glucocorticoids: Involvement of IL-1
por: Kovalovsky, D., et al.

Integrating the universe of regulatory cells in cancer. A major hurdle for successful immunotherapy
Publicado: (2007)

Integrating the universe of regulatory cells in cancer. A major hurdle for successful immunotherapy
por: Ilarregui, J.M., et al.

Tolerogenic dendritic cells in the control of autoimmune neuroinflammation: An emerging role of protein-glycan interactions
por: Ilarregui, Juan Martín
Publicado: (2010)

Tolerogenic dendritic cells in the control of autoimmune neuroinflammation: An emerging role of protein-glycan interactions
por: Ilarregui, J.M., et al.

Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
Publicado: (2014)