cAMP analogs and selective inhibitors used to study low Km Mucor rouxii cAMP phosphodiesterase

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1. 1. The sensitivity of partially purified low Km, phosphodiesterase (PDE) from Mucor rouxii to pharmacological agents and cAMP analogs was studied. The IC50 obtained were compared with those reported for PDEs from higher eukaryotes. 2. 2. The best inhibitors of the hydrolysis of 1 gmM cAMP were SQ...

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Detalles Bibliográficos
Autores principales: Tomes, C., Moreno, S.
Formato: JOUR
Materias:
1 ethyl 4 hydrazino 1h pyrazolo[3,4 b]pyridine 5 carboxylic acid ethyl ester
4 (3 butoxy 4 methoxybenzyl) 2 imidazolidinone
4,5 dihydro 6 [4 (1h imidazol 1 yl)phenyl] 5 methyl 3(2h) pyridazinone
6 [4 (3 methylureido)phenyl] 3(2h) pyridazinone
amrinone
cilostamide
cilostazol
cyclic amp
dipyridamole
etazolate
imazodan
isobutylmethylxanthine
milrinone
papaverine
phosphodiesterase
phosphodiesterase inhibitor
rolipram
sq 65442
theophylline
unclassified drug
article
fungus
mucor
nonhuman
1-Methyl-3-isobutylxanthine
3',5'-Cyclic-Nucleotide Phosphodiesterase
Centrifugation, Density Gradient
Cyclic AMP
Cyclic GMP
Dipyridamole
Hydrolysis
Mucor
Nicotinic Acids
Papaverine
Pyridazines
Support, Non-U.S. Gov't
Theophylline
Amylomyces rouxii
Fungi
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020711X_v22_n9_p1047_Tomes
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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