Trypanosoma cruzi infection imparts a regulatory program in dendritic cells and T cells via galectin-1-dependent mechanisms

Galectin-1 (Gal-1), an endogenous glycan-binding protein, is widely distributed at sites of inflammation and microbial invasion. Despite considerable progress regarding the immunoregulatory activity of this lectin, the role of endogenous Gal-1 during acute parasite infections is uncertain. In this s...

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Detalles Bibliográficos
Autores principales:	Poncini, C.V., Ilarregui, J.M., Batalla, E.I., Engels, S., Cerliani, J.P., Cucher, M.A., Van Kooyk, Y., González-Cappa, S.M., Rabinovich, G.A.
Formato:	JOUR
Materias:	CD4 antigen galectin 1 interleukin 10 interleukin 17 interleukin 2 receptor alpha transcription factor FOXP3 transforming growth factor beta1 gamma interferon IDO1 protein, mouse IL10 protein, mouse indoleamine 2,3 dioxygenase Pdcd1lg2 protein, mouse programmed death 1 ligand 2 analysis of variance animal cell animal experiment animal model animal tissue Article CD8+ T lymphocyte cell activation cell differentiation cell survival cell viability Chagas disease confocal microscopy controlled study cytokine production dendritic cell disease predisposition glycosylation homeostasis immunoblotting immunogenicity immunomodulation lymphocyte proliferation male mononuclear cell mouse nonhuman pathogen load priority journal protein analysis protein binding protein function quantitative analysis real time polymerase chain reaction T lymphocyte Th1 cell Th17 cell upregulation animal Bagg albino mouse biosynthesis C3H mouse cytology genetics immunology knockout mouse lymph node metabolism mortality parasite load parasitology regulatory T lymphocyte Trypanosoma cruzi Animals CD8-Positive T-Lymphocytes Chagas Disease Dendritic Cells Galectin 1 Indoleamine-Pyrrole 2,3,-Dioxygenase Interferon-gamma Interleukin-10 Lymph Nodes Male Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Knockout Parasite Load Programmed Cell Death 1 Ligand 2 Protein T-Lymphocytes, Regulatory Transforming Growth Factor beta1
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00221767_v195_n7_p3311_Poncini
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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