The enzyme NBAD-synthase plays diverse roles during the life cycle of Drosophila melanogaster
This report shows the biochemical characterization and life cycle-dependent expression of Drosophila melanogaster N-β-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown cut...
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| Autores principales: | , , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00221910_v56_n1_p8_Perez |
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| Sumario: | This report shows the biochemical characterization and life cycle-dependent expression of Drosophila melanogaster N-β-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis expression our immunodetection experiments show the novel localization of NBAD-synthase in different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme involved in different, previously unknown, time- and tissue-dependent processes. © 2009 Elsevier Ltd. All rights reserved. |
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