Exploring the molecular basis of action of the passive antiglucocorticoid 21-hydroxy-6,19-epoxyprogesterone

21-Hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a selective antiglucocorticoid that lacks the bulky substituent at C-11 found in active antagonists of the glucocorticoid receptor (GR). Ligand-free GR ligand-binding domain (LBD) and GR LBD complexed with 21OH-6,19OP or the agonist dexamethasone we...

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Detalles Bibliográficos
Autores principales: Álvarez, L.D., Martí, M.A., Veleiro, A.S., Presman, D.M., Estrin, D.A., Pecci, A., Burton, G.
Formato: JOUR
Materias:
21 hydroxy 6,19 epoxyprogesterone
dexamethasone
glucocorticoid antagonist
glucocorticoid receptor
homodimer
transcriptome
unclassified drug
animal cell
article
binding affinity
drug mechanism
gene activation
gene location
gene translocation
molecular dynamics
mouse
nonhuman
transactivation
Animals
Binding Sites
Cell Line
Cell Nucleus
Crystallography, X-Ray
Dexamethasone
Dimerization
Genes, Reporter
Ligands
Mice
Microscopy, Confocal
Models, Molecular
Progesterone
Promoter Regions (Genetics)
Protein Transport
Receptors, Glucocorticoid
Trans-Activation (Genetics)
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00222623_v51_n5_p1352_Alvarez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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