Nifedipine-mediated mobilization of intracellular calcium stores increases spontaneous neurotransmitter release at neonatal rat motor nerve terminals

The modulation of spontaneous release of acetylcholine by specific Ca2+ channel blockers was studied at neonatal rat neuromuscular junction. During early postnatal periods (0-4 days), blockers of N- and P/Q-type Ca2+ channels did not affect miniature endplate potential (MEPP) frequency. Unexpectedly...

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Detalles Bibliográficos
Autores principales: Piriz, J., Siri, M.D.R., Pagani, R., Uchitel, O.D.
Formato: JOUR
Materias:
calciseptine
calcium channel blocking agent
calcium channel L type
calcium ion
isradipine
neurotransmitter
nifedipine
nitrendipine
omega agatoxin VIA
ryanodine
ryanodine receptor
thapsigargin
animal tissue
article
calcium cell level
calcium transport
concentration response
controlled study
diagnostic value
drug effect
drug mechanism
drug use
long term potentiation
miniature endplate potential
nerve ending
neuromuscular synapse
neurotransmitter release
newborn
nonhuman
priority journal
protein expression
rat
time series analysis
Age Factors
Animals
Calcium
Calcium Channel Blockers
Electrophysiology
Intracellular Fluid
Motor Endplate
Motor Neurons
Neurotransmitter Agents
Nifedipine
Rats
Rats, Sprague-Dawley
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00223565_v306_n2_p658_Piriz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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