Sodium-retaining activity of some natural and synthetic 21-deoxysteroids

The effect of progesterone and six other C21 -deoxysteroids on renal sodium retention by male adrenaleotomized rats was compared with the effect exerted by the natural corticoids aldosterone, 11-deoxycorticosterone, and corticosterone. Steroids were active in the following order: aldosterone > 11...

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Autores principales:	Burton, G., Galigniana, M., De Lavallaz, S., Brachet-Cota, A.L., Sproviero, E.M., Ghini, A.A., Lantos, C.P., Damasco, M.C.
Formato:	JOUR
Materias:	11,19 oxidoprogesterone 11beta,17beta dihydroxy 6 methyl 17alpha (1 propynyl)androsta 1,4,6 trien 3 one 21 deoxycorticosterone 5alpha pregnane 3,20 dione 6,19 oxido 11 oxoprogesterone 6,19 oxidoprogesterone aldosterone corticosterone deoxycorticosterone mineralocorticoid receptor pregnanedione progesterone progesterone derivative transcortin unclassified drug adrenalectomy animal experiment animal tissue article controlled study dose response drug conformation drug half life intramuscular drug administration intraperitoneal drug administration male nonhuman potassium urine level priority journal rat receptor affinity sodium retention sodium urine level subcutaneous drug administration Adrenal Glands Adrenalectomy Aldosterone Animal Comparative Study Cytosol Desoxycorticosterone Half-Life Kidney Male Molecular Conformation Potassium Progesterone Rats Rats, Sprague-Dawley Receptors, Steroid Sodium Steroids Support, Non-U.S. Gov't Tritium
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0026895X_v47_n3_p535_Burton
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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