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spelling todo:paper_00280836_v456_n7223_p755_Yu2023-10-03T14:38:33Z Negative feedback that improves information transmission in yeast signalling Yu, R.C. Pesce, C.G. Colman-Lerner, A. Lok, L. Pincus, D. Serra, E. Holl, M. Benjamin, K. Gordon, A. Brent, R. g protein signalling protein sst2 membrane protein mitogen activated protein kinase mitogen activated protein kinase fus3 sex pheromone unclassified drug concentration (composition) dose-response relationship enzyme activity feedback mechanism mating behavior protein sex pheromone signaling yeast article cell communication cell function dose response downstream processing hormone release information dissemination ligand binding negative feedback nonhuman priority journal receptor binding Saccharomyces cerevisiae signal transduction yeast cell Saccharomyces cerevisiae Haploid Saccharomyces cerevisiae yeast cells use a prototypic cell signalling system to transmit information about the extracellular concentration of mating pheromone secreted by potential mating partners. The ability of cells to respond distinguishably to different pheromone concentrations depends on how much information about pheromone concentration the system can transmit. Here we show that the mitogen-activated protein kinase Fus3 mediates fast-acting negative feedback that adjusts the dose response of the downstream system response to match the dose response of receptor-ligand binding. This 'dose-response alignment', defined by a linear relationship between receptor occupancy and downstream response, can improve the fidelity of information transmission by making downstream responses corresponding to different receptor occupancies more distinguishable and reducing amplification of stochastic noise during signal transmission. We also show that one target of the feedback is a previously uncharacterized signal-promoting function of the regulator of G-protein signalling protein Sst2. Our work suggests that negative feedback is a general mechanism used in signalling systems to align dose responses and thereby increase the fidelity of information transmission. ©2008 Macmillan Publishers Limited. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00280836_v456_n7223_p755_Yu
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic g protein signalling protein sst2
membrane protein
mitogen activated protein kinase
mitogen activated protein kinase fus3
sex pheromone
unclassified drug
concentration (composition)
dose-response relationship
enzyme activity
feedback mechanism
mating behavior
protein
sex pheromone
signaling
yeast
article
cell communication
cell function
dose response
downstream processing
hormone release
information dissemination
ligand binding
negative feedback
nonhuman
priority journal
receptor binding
Saccharomyces cerevisiae
signal transduction
yeast cell
Saccharomyces cerevisiae
spellingShingle g protein signalling protein sst2
membrane protein
mitogen activated protein kinase
mitogen activated protein kinase fus3
sex pheromone
unclassified drug
concentration (composition)
dose-response relationship
enzyme activity
feedback mechanism
mating behavior
protein
sex pheromone
signaling
yeast
article
cell communication
cell function
dose response
downstream processing
hormone release
information dissemination
ligand binding
negative feedback
nonhuman
priority journal
receptor binding
Saccharomyces cerevisiae
signal transduction
yeast cell
Saccharomyces cerevisiae
Yu, R.C.
Pesce, C.G.
Colman-Lerner, A.
Lok, L.
Pincus, D.
Serra, E.
Holl, M.
Benjamin, K.
Gordon, A.
Brent, R.
Negative feedback that improves information transmission in yeast signalling
topic_facet g protein signalling protein sst2
membrane protein
mitogen activated protein kinase
mitogen activated protein kinase fus3
sex pheromone
unclassified drug
concentration (composition)
dose-response relationship
enzyme activity
feedback mechanism
mating behavior
protein
sex pheromone
signaling
yeast
article
cell communication
cell function
dose response
downstream processing
hormone release
information dissemination
ligand binding
negative feedback
nonhuman
priority journal
receptor binding
Saccharomyces cerevisiae
signal transduction
yeast cell
Saccharomyces cerevisiae
description Haploid Saccharomyces cerevisiae yeast cells use a prototypic cell signalling system to transmit information about the extracellular concentration of mating pheromone secreted by potential mating partners. The ability of cells to respond distinguishably to different pheromone concentrations depends on how much information about pheromone concentration the system can transmit. Here we show that the mitogen-activated protein kinase Fus3 mediates fast-acting negative feedback that adjusts the dose response of the downstream system response to match the dose response of receptor-ligand binding. This 'dose-response alignment', defined by a linear relationship between receptor occupancy and downstream response, can improve the fidelity of information transmission by making downstream responses corresponding to different receptor occupancies more distinguishable and reducing amplification of stochastic noise during signal transmission. We also show that one target of the feedback is a previously uncharacterized signal-promoting function of the regulator of G-protein signalling protein Sst2. Our work suggests that negative feedback is a general mechanism used in signalling systems to align dose responses and thereby increase the fidelity of information transmission. ©2008 Macmillan Publishers Limited. All rights reserved.
format JOUR
author Yu, R.C.
Pesce, C.G.
Colman-Lerner, A.
Lok, L.
Pincus, D.
Serra, E.
Holl, M.
Benjamin, K.
Gordon, A.
Brent, R.
author_facet Yu, R.C.
Pesce, C.G.
Colman-Lerner, A.
Lok, L.
Pincus, D.
Serra, E.
Holl, M.
Benjamin, K.
Gordon, A.
Brent, R.
author_sort Yu, R.C.
title Negative feedback that improves information transmission in yeast signalling
title_short Negative feedback that improves information transmission in yeast signalling
title_full Negative feedback that improves information transmission in yeast signalling
title_fullStr Negative feedback that improves information transmission in yeast signalling
title_full_unstemmed Negative feedback that improves information transmission in yeast signalling
title_sort negative feedback that improves information transmission in yeast signalling
url http://hdl.handle.net/20.500.12110/paper_00280836_v456_n7223_p755_Yu
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AT pincusd negativefeedbackthatimprovesinformationtransmissioninyeastsignalling
AT serrae negativefeedbackthatimprovesinformationtransmissioninyeastsignalling
AT hollm negativefeedbackthatimprovesinformationtransmissioninyeastsignalling
AT benjamink negativefeedbackthatimprovesinformationtransmissioninyeastsignalling
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AT brentr negativefeedbackthatimprovesinformationtransmissioninyeastsignalling
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