Negative feedback that improves information transmission in yeast signalling
Haploid Saccharomyces cerevisiae yeast cells use a prototypic cell signalling system to transmit information about the extracellular concentration of mating pheromone secreted by potential mating partners. The ability of cells to respond distinguishably to different pheromone concentrations depends...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00280836_v456_n7223_p755_Yu |
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todo:paper_00280836_v456_n7223_p755_Yu2023-10-03T14:38:33Z Negative feedback that improves information transmission in yeast signalling Yu, R.C. Pesce, C.G. Colman-Lerner, A. Lok, L. Pincus, D. Serra, E. Holl, M. Benjamin, K. Gordon, A. Brent, R. g protein signalling protein sst2 membrane protein mitogen activated protein kinase mitogen activated protein kinase fus3 sex pheromone unclassified drug concentration (composition) dose-response relationship enzyme activity feedback mechanism mating behavior protein sex pheromone signaling yeast article cell communication cell function dose response downstream processing hormone release information dissemination ligand binding negative feedback nonhuman priority journal receptor binding Saccharomyces cerevisiae signal transduction yeast cell Saccharomyces cerevisiae Haploid Saccharomyces cerevisiae yeast cells use a prototypic cell signalling system to transmit information about the extracellular concentration of mating pheromone secreted by potential mating partners. The ability of cells to respond distinguishably to different pheromone concentrations depends on how much information about pheromone concentration the system can transmit. Here we show that the mitogen-activated protein kinase Fus3 mediates fast-acting negative feedback that adjusts the dose response of the downstream system response to match the dose response of receptor-ligand binding. This 'dose-response alignment', defined by a linear relationship between receptor occupancy and downstream response, can improve the fidelity of information transmission by making downstream responses corresponding to different receptor occupancies more distinguishable and reducing amplification of stochastic noise during signal transmission. We also show that one target of the feedback is a previously uncharacterized signal-promoting function of the regulator of G-protein signalling protein Sst2. Our work suggests that negative feedback is a general mechanism used in signalling systems to align dose responses and thereby increase the fidelity of information transmission. ©2008 Macmillan Publishers Limited. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00280836_v456_n7223_p755_Yu |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
g protein signalling protein sst2 membrane protein mitogen activated protein kinase mitogen activated protein kinase fus3 sex pheromone unclassified drug concentration (composition) dose-response relationship enzyme activity feedback mechanism mating behavior protein sex pheromone signaling yeast article cell communication cell function dose response downstream processing hormone release information dissemination ligand binding negative feedback nonhuman priority journal receptor binding Saccharomyces cerevisiae signal transduction yeast cell Saccharomyces cerevisiae |
| spellingShingle |
g protein signalling protein sst2 membrane protein mitogen activated protein kinase mitogen activated protein kinase fus3 sex pheromone unclassified drug concentration (composition) dose-response relationship enzyme activity feedback mechanism mating behavior protein sex pheromone signaling yeast article cell communication cell function dose response downstream processing hormone release information dissemination ligand binding negative feedback nonhuman priority journal receptor binding Saccharomyces cerevisiae signal transduction yeast cell Saccharomyces cerevisiae Yu, R.C. Pesce, C.G. Colman-Lerner, A. Lok, L. Pincus, D. Serra, E. Holl, M. Benjamin, K. Gordon, A. Brent, R. Negative feedback that improves information transmission in yeast signalling |
| topic_facet |
g protein signalling protein sst2 membrane protein mitogen activated protein kinase mitogen activated protein kinase fus3 sex pheromone unclassified drug concentration (composition) dose-response relationship enzyme activity feedback mechanism mating behavior protein sex pheromone signaling yeast article cell communication cell function dose response downstream processing hormone release information dissemination ligand binding negative feedback nonhuman priority journal receptor binding Saccharomyces cerevisiae signal transduction yeast cell Saccharomyces cerevisiae |
| description |
Haploid Saccharomyces cerevisiae yeast cells use a prototypic cell signalling system to transmit information about the extracellular concentration of mating pheromone secreted by potential mating partners. The ability of cells to respond distinguishably to different pheromone concentrations depends on how much information about pheromone concentration the system can transmit. Here we show that the mitogen-activated protein kinase Fus3 mediates fast-acting negative feedback that adjusts the dose response of the downstream system response to match the dose response of receptor-ligand binding. This 'dose-response alignment', defined by a linear relationship between receptor occupancy and downstream response, can improve the fidelity of information transmission by making downstream responses corresponding to different receptor occupancies more distinguishable and reducing amplification of stochastic noise during signal transmission. We also show that one target of the feedback is a previously uncharacterized signal-promoting function of the regulator of G-protein signalling protein Sst2. Our work suggests that negative feedback is a general mechanism used in signalling systems to align dose responses and thereby increase the fidelity of information transmission. ©2008 Macmillan Publishers Limited. All rights reserved. |
| format |
JOUR |
| author |
Yu, R.C. Pesce, C.G. Colman-Lerner, A. Lok, L. Pincus, D. Serra, E. Holl, M. Benjamin, K. Gordon, A. Brent, R. |
| author_facet |
Yu, R.C. Pesce, C.G. Colman-Lerner, A. Lok, L. Pincus, D. Serra, E. Holl, M. Benjamin, K. Gordon, A. Brent, R. |
| author_sort |
Yu, R.C. |
| title |
Negative feedback that improves information transmission in yeast signalling |
| title_short |
Negative feedback that improves information transmission in yeast signalling |
| title_full |
Negative feedback that improves information transmission in yeast signalling |
| title_fullStr |
Negative feedback that improves information transmission in yeast signalling |
| title_full_unstemmed |
Negative feedback that improves information transmission in yeast signalling |
| title_sort |
negative feedback that improves information transmission in yeast signalling |
| url |
http://hdl.handle.net/20.500.12110/paper_00280836_v456_n7223_p755_Yu |
| work_keys_str_mv |
AT yurc negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT pescecg negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT colmanlernera negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT lokl negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT pincusd negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT serrae negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT hollm negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT benjamink negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT gordona negativefeedbackthatimprovesinformationtransmissioninyeastsignalling AT brentr negativefeedbackthatimprovesinformationtransmissioninyeastsignalling |
| _version_ |
1807314947829399552 |