Deterministic Limit of Intracellular Calcium Spikes

In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with...

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Detalles Bibliográficos
Autores principales: Voorsluijs, V., Dawson, S.P., De Decker, Y., Dupont, G.
Formato: JOUR
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00319007_v122_n8_p_Voorsluijs
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00319007_v122_n8_p_Voorsluijs2023-10-03T14:42:51Z Deterministic Limit of Intracellular Calcium Spikes Voorsluijs, V. Dawson, S.P. De Decker, Y. Dupont, G. In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism. © 2019 American Physical Society. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00319007_v122_n8_p_Voorsluijs
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism. © 2019 American Physical Society.
format JOUR
author Voorsluijs, V.
Dawson, S.P.
De Decker, Y.
Dupont, G.
spellingShingle Voorsluijs, V.
Dawson, S.P.
De Decker, Y.
Dupont, G.
Deterministic Limit of Intracellular Calcium Spikes
author_facet Voorsluijs, V.
Dawson, S.P.
De Decker, Y.
Dupont, G.
author_sort Voorsluijs, V.
title Deterministic Limit of Intracellular Calcium Spikes
title_short Deterministic Limit of Intracellular Calcium Spikes
title_full Deterministic Limit of Intracellular Calcium Spikes
title_fullStr Deterministic Limit of Intracellular Calcium Spikes
title_full_unstemmed Deterministic Limit of Intracellular Calcium Spikes
title_sort deterministic limit of intracellular calcium spikes
url http://hdl.handle.net/20.500.12110/paper_00319007_v122_n8_p_Voorsluijs
work_keys_str_mv AT voorsluijsv deterministiclimitofintracellularcalciumspikes
AT dawsonsp deterministiclimitofintracellularcalciumspikes
AT dedeckery deterministiclimitofintracellularcalciumspikes
AT dupontg deterministiclimitofintracellularcalciumspikes
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