Synthesis of 6-azaprogesterone and 19-hydroxy-6-azasteroids

19-Hydroxy-6-azapregnanes were obtained from pregnenolone via a 7-azido-5-oxo-6-nor-5,7-secopregnane intermediate. The 6-azapregnane core was built in good yield in a straightforward way from the secosteroid, by means of a Staudinger (aza-Wittig) reaction. Finally the 19-hydroxy-6-azapregnane was tr...

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Detalles Bibliográficos
Autores principales: Martínez, M.D., Edelsztein, V.C., Durán, F.J., Di Chenna, P.H., Burton, G.
Formato: JOUR
Materias:
19-Hydroxypregnane
6-Azaprogesterone
Azasteroids
Gestagenic activity
18 hydroxy 20 oxosteroid
18 hydroxydeoxycorticosterone
18 hydroxyprogesterone
19 hydroxy 3 oxosteroid
19 hydroxy 6 (tert butoxycarbonyl) 6 aza 4 pregnene 3,20 dione
19 hydroxy 6 azaprogesterone
19 hydroxy 6 azasteroid
3beta tert butyldimethylsilyloxy 19 formyloxy 6 aza 5 pregnen 20 one
3beta tert butyldimethylsilyloxy 6 (tert butoxycarbonyl) 19 formyloxy 6 aza 4 pregnen 20 one
3beta tert butyldimethylsilyloxy 7 azido 19 formyloxy 6 nor 5,7 secopregnane 5,20 dione
3beta,19 dihydroxy 6 (tert butoxycarbonyl) 6 aza 4 pregnen 20 one
6 azaprogesterone
azasteroid
gestagen
manganese dioxide
pregnenolone
progesterone receptor
secosteroid
unclassified drug
acylation
animal cell
article
chemical bond
controlled study
cyclization
drug structure
drug synthesis
human
nonhuman
reduction
structure activity relation
Animals
Cercopithecus aethiops
COS Cells
Cyclization
Gene Expression
Genes, Reporter
Humans
Luciferases
Pregnanes
Progesterone
Promoter Regions, Genetic
Receptors, Progesterone
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0039128X_v78_n1_p34_Martinez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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