Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules

A route based on calcium phosphate emulsions with addition of glycolic acid as pore former was developed for synthesizing porous nanocrystalline biphasic calcium phosphate ceramics. The method is low cost and gives a biphasic calcium phosphate composed of 88% β-tricalcium phosphate and 12% hydroxyap...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcés Villalá, M.A., Calvo Guirado, J.L., Granados, D., Limandri, S.P., Galván Josa, V.
Formato: JOUR
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00498246_v46_n4_p237_GarcesVillala
Aporte de:
id todo:paper_00498246_v46_n4_p237_GarcesVillala
record_format dspace
spelling todo:paper_00498246_v46_n4_p237_GarcesVillala2023-10-03T14:52:44Z Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules Garcés Villalá, M.A. Calvo Guirado, J.L. Granados, D. Limandri, S.P. Galván Josa, V. A route based on calcium phosphate emulsions with addition of glycolic acid as pore former was developed for synthesizing porous nanocrystalline biphasic calcium phosphate ceramics. The method is low cost and gives a biphasic calcium phosphate composed of 88% β-tricalcium phosphate and 12% hydroxyapatite. The material obtained is characterized by scanning electron microscopy, X-ray diffraction and X-ray fluorescence techniques, and the specific surface area is determined by the Brunauer, Emmett and Teller method. The small crystalline domain sizes obtained (68 and 87 nm for β-tricalcium phosphate and hydroxyapatite phases, respectively) allow a major contact reaction and stability in the interphase between the implanted material and natural bone, as well as a better promotion effect on the early bone in-growth. The improvement of the physical, chemical and structural properties by the balanced combination of the ceramic phases, the small crystallite size, the high porosity and high specific surface area obtained is a desirable characteristic in bone tissue engineering and encourages the performance of animal studies in vivo to evaluate their use for applications such as bone replacement in humans. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00498246_v46_n4_p237_GarcesVillala
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description A route based on calcium phosphate emulsions with addition of glycolic acid as pore former was developed for synthesizing porous nanocrystalline biphasic calcium phosphate ceramics. The method is low cost and gives a biphasic calcium phosphate composed of 88% β-tricalcium phosphate and 12% hydroxyapatite. The material obtained is characterized by scanning electron microscopy, X-ray diffraction and X-ray fluorescence techniques, and the specific surface area is determined by the Brunauer, Emmett and Teller method. The small crystalline domain sizes obtained (68 and 87 nm for β-tricalcium phosphate and hydroxyapatite phases, respectively) allow a major contact reaction and stability in the interphase between the implanted material and natural bone, as well as a better promotion effect on the early bone in-growth. The improvement of the physical, chemical and structural properties by the balanced combination of the ceramic phases, the small crystallite size, the high porosity and high specific surface area obtained is a desirable characteristic in bone tissue engineering and encourages the performance of animal studies in vivo to evaluate their use for applications such as bone replacement in humans. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.
format JOUR
author Garcés Villalá, M.A.
Calvo Guirado, J.L.
Granados, D.
Limandri, S.P.
Galván Josa, V.
spellingShingle Garcés Villalá, M.A.
Calvo Guirado, J.L.
Granados, D.
Limandri, S.P.
Galván Josa, V.
Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules
author_facet Garcés Villalá, M.A.
Calvo Guirado, J.L.
Granados, D.
Limandri, S.P.
Galván Josa, V.
author_sort Garcés Villalá, M.A.
title Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules
title_short Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules
title_full Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules
title_fullStr Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules
title_full_unstemmed Synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules
title_sort synthesis, chemical and microstructural characterization of micro macroporous biphasic calcium phosphate granules
url http://hdl.handle.net/20.500.12110/paper_00498246_v46_n4_p237_GarcesVillala
work_keys_str_mv AT garcesvillalama synthesischemicalandmicrostructuralcharacterizationofmicromacroporousbiphasiccalciumphosphategranules
AT calvoguiradojl synthesischemicalandmicrostructuralcharacterizationofmicromacroporousbiphasiccalciumphosphategranules
AT granadosd synthesischemicalandmicrostructuralcharacterizationofmicromacroporousbiphasiccalciumphosphategranules
AT limandrisp synthesischemicalandmicrostructuralcharacterizationofmicromacroporousbiphasiccalciumphosphategranules
AT galvanjosav synthesischemicalandmicrostructuralcharacterizationofmicromacroporousbiphasiccalciumphosphategranules
_version_ 1807318740332707840