Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae

Endocrine-disrupting chemicals can influence the hypothalamus-pituitary- gonad axis and possibly affect reproduction in vertebrates. We analyzed the effect of 30-day endosulfan (ES) exposure in sexually undifferentiated larvae of the cichlid fish Cichlasoma dimerus. The number, area, mean cytoplasmi...

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Detalles Bibliográficos
Autores principales: Piazza, Y.G., Pandolfi, M., Lo Nostro, F.L.
Formato: JOUR
Materias:
endosulfan
follitropin beta subunit
gonadorelin
cell organelle
concentration (composition)
developmental biology
diameter
endocrine disruptor
fish
functional morphology
hormone
larva
organochlorine
physiological response
pollution exposure
population structure
reproduction
article
cell population
Cichlasoma dimerus
cichlid
controlled study
cytoplasm
gonad development
nonhuman
nucleus accumbens
optical density
priority journal
protein secretion
protein synthesis
Animals
Cichlids
Endosulfan
Environmental Exposure
Follicle Stimulating Hormone
Gonadotrophs
Gonadotropin-Releasing Hormone
Gonads
Hydrocarbons, Chlorinated
Insecticides
Larva
Neurons
Animalia
Cichlasoma
Cichlidae
Vertebrata
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00904341_v61_n2_p300_Piazza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Endocrine-disrupting chemicals can influence the hypothalamus-pituitary- gonad axis and possibly affect reproduction in vertebrates. We analyzed the effect of 30-day endosulfan (ES) exposure in sexually undifferentiated larvae of the cichlid fish Cichlasoma dimerus. The number, area, mean cytoplasmic and nuclear diameter, and mean cytoplasmic optical density of gonadotropin-releasing hormone (GnRH) I, II, and III immunoreactive (ir-) neurons and β follicle-stimulating hormone (βFSH) ir-cells were measured. Animals exposed to the highest ES concentration (0.1 μg/l) showed a decrease in GnRH I nucleus/cytoplasm area ratio upon exposure. Nuclear area and mean nuclear diameter of βFSH ir-cells was higher in ES treated fish. βFSH nucleus/cytoplasm area ratio was high in exposed animals, and animals exposed to 0.1 μg/l ES showed smaller mean cytoplasmic optical density. These findings suggest that ES affects GnRH I and βFSH protein synthesis/release. However, these responses seem to be insufficient to affect gonadal differentiation at this stage of development. © 2010 Springer Science+Business Media, LLC.

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