16-hydroxylated withanolides from Exodeconus maritimus

In addition to the known compounds withanolide A (4), withanone (5), and NIC-3 (6), three 16-hydroxylated withanolides were isolated from Exodeconus maritimus. The new withanolides were identified as 6α,7α-epoxy-5α,16β- dihydroxy-1-oxowitha-2,17(20),24-trienolide (exodeconolide A, 1), 6α,7α- epoxy-5...

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Detalles Bibliográficos
Autores principales: Gil, R.R., Misico, R.I., Sotes, I.R., Oberti, J.C., Veleiro, A.S., Burton, G.
Formato: JOUR
Materias:
exodeconolide a
exodeconolide b
exodeconolide c
nic 3
unclassified drug
withanolide
withanolide a
withanone
antiinflammatory activity
antimicrobial activity
antineoplastic activity
article
defense mechanism
drug isolation
drug structure
immunomodulation
mass spectrometry
nuclear magnetic resonance
phytochemistry
species differentiation
structure activity relation
taxonomy
Exodeconus maritimus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01633864_v60_n6_p568_Gil
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:In addition to the known compounds withanolide A (4), withanone (5), and NIC-3 (6), three 16-hydroxylated withanolides were isolated from Exodeconus maritimus. The new withanolides were identified as 6α,7α-epoxy-5α,16β- dihydroxy-1-oxowitha-2,17(20),24-trienolide (exodeconolide A, 1), 6α,7α- epoxy-5α,16α-dihydroxy-l-oxowitha-2,17(20),24-trienolide (exodeconolide B, 2), and 6α7α-epoxy-5α,16α,17α-trihydroxy-1-oxowitha-2, 24-dienolide (exodeconolide C, 3), by a combination of spectroscopic (1D and 2D NMR, MS) and chemical methods with the aid of molecular modeling.

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