Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases

A novel SR protein-specific kinase (SRPK) from the SRPK family was identified for the first time in a protozoan organism. The primary structure of the protein, named TcSRPK, presents a significant degree of identity with other metazoan members of the family. In vitro phosphorylation experiments show...

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Detalles Bibliográficos
Autores principales: Portal, D., Lobo, G.S., Kadener, S., Prasad, J., Espinosa, J.M., Pereira, C.A., Tang, Z., Lin, R.-J., Manley, J.L., Kornblihtt, A.R., Flawiá, M.M., Torres, H.N.
Formato: JOUR
Materias:
SR protein kinase
SR-network
SRPK
Trans-splicing
Trypanosoma cruzi
cell extract
epitope
fibronectin
isoenzyme
monoclonal antibody
monoclonal antibody 104
protein kinase
protein S 100
protozoal protein
ribonucleoprotein
RNA
serine arginine protein
serine arginine protein kinase
splicing factor 2
unclassified drug
alternative RNA splicing
article
cell nucleus
controlled study
enzyme phosphorylation
enzyme specificity
exon
fungal strain
gene
HeLa cell
human
human cell
in vitro study
in vivo study
inhibition kinetics
metazoon
molecular recognition
nonhuman
nucleotide sequence
phenotype
priority journal
protein expression
protein family
protein function
protein structure
Schizosaccharomyces pombe
sequence homology
Amino Acid Sequence
Animals
Antibodies, Monoclonal
Cloning, Molecular
Genes, Protozoan
Globins
Hela Cells
Humans
Molecular Sequence Data
Protein Structure, Tertiary
Protein-Serine-Threonine Kinases
Schizosaccharomyces
Sequence Alignment
Sequence Homology, Amino Acid
Species Specificity
Metazoa
Protozoa
Trypanosoma
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01666851_v127_n1_p9_Portal
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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