Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes

Phosphatidylinositol (PtdIns) metabolism through phosphatidylinositol kinase (PIKs) activities plays a central role in different signaling pathways. In Trypanosoma cruzi, causative agent of Chagas disease, PIKs have been proposed as target for drug design in order to combat this pathogen. In this wo...

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Detalles Bibliográficos
Autores principales: Gimenez, A.M., Gesumaría, M.C., Schoijet, A.C., Alonso, G.D., Flawiá, M.M., Racagni, G.E., Machado, E.E.
Formato: JOUR
Materias:
Kinase activity
Phosphatidylinositol-3 kinase
Phosphoinositide kinase
Phospholipid signaling
T. cruzi epimastigotes
TcPI3K
2 morpholino 8 phenylchromone
adenosine
calcium ion
deoxycholate sodium
heparin
phosphatidic acid
phosphatidylinositol 3 kinase
phosphatidylinositol 4 phosphate kinase
phosphatidylinositol 4,5 bisphosphate 3 kinase
phosphatidylinositol kinase
protozoal protein
spermine
wortmannin
enzyme activator
enzyme inhibitor
phosphatidylinositol
Article
controlled study
cytosolic fraction
enzyme activity
enzyme phosphorylation
epimastigote
molecular cloning
nonhuman
Northern blotting
phylogeny
priority journal
protein expression
signal transduction
Trypanosoma cruzi
Western blotting
antagonists and inhibitors
Chagas disease
classification
drug design
enzymology
growth, development and aging
human
metabolism
parasitology
phosphorylation
Chagas Disease
Cloning, Molecular
Drug Design
Enzyme Activators
Enzyme Inhibitors
Humans
Phosphatidylinositol 3-Kinases
Phosphatidylinositols
Phosphorylation
Phylogeny
Protozoan Proteins
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01666851_v203_n1-2_p14_Gimenez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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