Classical membrane progesterone receptors in murine mammary carcinomas: Agonistic effects of progestins and RU-486 mediating rapid non-genomic effects

In this article, we demonstrate the expression of functional progesterone binding sites at the cell membrane in murine mammary carcinomas that are stimulated by progestins and inhibited by antiprogestins. Using confocal immunofluorescence, ligand binding and cell compartment-specific western blots,...

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Detalles Bibliográficos
Autores principales:	Bottino, M.C., Cerliani, J.P., Rojas, P., Giulianelli, S., Soldati, R., Mondillo, C., Gorostiaga, M.A., Pignataro, O.P., Calvo, J.C., Gutkind, J.S., Amornphimoltham, P., Molinolo, A.A., Lüthy, I.A., Lanari, C.
Formato:	JOUR
Materias:	Antiprogestins Breast cancer treatment Mammary carcinomas Membrane progesterone receptors Non-genomic effects Progesterone receptor isoforms: Membrane-initiated steroid signaling Progestins 2 (2 amino 3 methoxyphenyl)chromone cyclin D1 DNA hydroxytamoxifen medroxyprogesterone acetate mifepristone mitogen activated protein kinase progesterone receptor thromboplastin animal experiment animal model animal tissue article binding site breast carcinoma cancer growth cancer regression cell membrane cell proliferation concentration response controlled study drug dose comparison drug effect enzyme activation female human human cell immunofluorescence test in vitro study in vivo study ligand binding mouse nonhuman nucleotide sequence priority journal protein DNA binding protein expression Western blotting Animals Female Gene Expression Regulation, Neoplastic Mammary Neoplasms, Animal Medroxyprogesterone Acetate Mice Mice, Inbred BALB C Microscopy, Confocal Microscopy, Fluorescence Mifepristone Neoplasm Transplantation Receptors, Progesterone Steroids
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_01676806_v126_n3_p621_Bottino
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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