Early response and induced tolerance to cycloheximide in Neurospora crassa

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Incubation of Neurospora crassa mycelia with low doses of cycloheximide induces the expression of several genes. After 6 h in the presence of cycloheximide, mycelia become tolerant to further additions of the drug and the rate of protein synthesis exhibits a lower sensitivity to it. The polypeptide...

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Detalles Bibliográficos
Autores principales: Grotewold, E., Taccioli, G.E., Aisemberg, G.O., Judewicz, N.D.
Formato: JOUR
Materias:
Cycloheximide
Induced tolerance
Neurospora crassa
Stress proteins
cycloheximide
drug response
drug tolerance
fungus
heredity
neurospora crassa
nonhuman
Drug Tolerance
Electrophoresis, Polyacrylamide Gel
Fungal Proteins
Gene Expression Regulation
Genes, Fungal
Kinetics
Neurospora
RNA, Fungal
Temperature
Transcription, Genetic
Translation, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01728083_v15_n6_p429_Grotewold
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Incubation of Neurospora crassa mycelia with low doses of cycloheximide induces the expression of several genes. After 6 h in the presence of cycloheximide, mycelia become tolerant to further additions of the drug and the rate of protein synthesis exhibits a lower sensitivity to it. The polypeptide pattern is indicative of a stress situation. © 1989 Springer-Verlag.

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