Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients

Objectives: To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. Methods: 17 patients, receiving TPN a...

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Detalles Bibliográficos
Autores principales: Menéndez, A.Ma., De Portela, Ma.L.P.M., Weisstaub, A., Montemerlo, H., Guidoni, Ma.E., Rusí, F., Zeni, S.
Formato: JOUR
Lenguaje:Spanish
Materias:
Critically ill patients with parenteral nutrition
Interleukin-6
Soluble receptor of interleukin-6, and C reactive protein
Zinc
C reactive protein
interleukin 6
interleukin 6 receptor
zinc
abdominal surgery
acute pancreatitis
adult
aged
article
clinical article
critically ill patient
diet supplementation
enzyme linked immunosorbent assay
female
human
ileus
inflammation
intestine cancer
intestine fistula
male
total parenteral nutrition
Adult
Aged
C-Reactive Protein
Critical Illness
Female
Humans
Male
Middle Aged
Parenteral Nutrition, Total
Receptors, Interleukin-6
Fistula
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02121611_v24_n3_p340_Menendez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_02121611_v24_n3_p340_Menendez
record_format dspace
spelling todo:paper_02121611_v24_n3_p340_Menendez2023-10-03T15:10:02Z Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients Menéndez, A.Ma. De Portela, Ma.L.P.M. Weisstaub, A. Montemerlo, H. Guidoni, Ma.E. Rusí, F. Zeni, S. Critically ill patients with parenteral nutrition Interleukin-6 Soluble receptor of interleukin-6, and C reactive protein Zinc C reactive protein interleukin 6 interleukin 6 receptor zinc abdominal surgery acute pancreatitis adult aged article clinical article critically ill patient diet supplementation enzyme linked immunosorbent assay female human ileus inflammation intestine cancer intestine fistula male total parenteral nutrition Adult Aged C-Reactive Protein Critical Illness Female Humans Interleukin-6 Male Middle Aged Parenteral Nutrition, Total Receptors, Interleukin-6 Zinc Fistula Objectives: To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. Methods: 17 patients, receiving TPN as a consequence of acute pancreatitis (n = 4) or after a major abdominal surgery due to intestinal cancer (n = 7), intestinal fístula (n = 3), intestinal obstruction (n = 2) or intestinal íleus (n = 1) were studied. At the beginning (To) and at the end of the TPN administration (6-21days) serum IL-6 and IL-6 sR were determined by ELISA; C-RP ultrasensitive (C-RP us) by inmunoturbidimetric method; Zn was determined in TPN and in plasma by Atomic Absorption Spectrometry. Characteristics of the patients were (mean ± SD and ranges): age: 60.6 ± 11.7 (37-77) years; BMI (kg/m2): 26.0 ± 3.4 (19.9-34.0). Results: The results (mean ± standard deviation and ranges) were: Zn provided by TPN (mg/d): 6.1 ± 2.0 (range 2.8 to 10.8). Biochemical levels were, at To and Tf, respectively: (mean±SD and ranges) were at To y Tf, respectively: Zn Pl (?g/dl): 104 ± 46 (35-177); 120 ± 55 (52-229); IL-6 (pg/mL) 93 ± 74 (10-262); 117 ± 180 (7-761); IL6sR (pg/mL): 1,012 ± 322 (589-1855); 1,269 ± 451 (631-2195); C-RP us (mg/L): 71 ± 63 (2-196); 65 ± 43 (0-137). There was no correlation between variations of IL6, IL6sR, C-RP, PlZn levels and the daily amount of Zn administered in the TPN mixtures. Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased Conclusions: the range of 2.8 to 10.8 mg/d of Zn administered in TPN mixtures did not exacerbate the inflammatory response. Fil:Zeni, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR Spanish info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_02121611_v24_n3_p340_Menendez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language Spanish
orig_language_str_mv Spanish
topic Critically ill patients with parenteral nutrition
Interleukin-6
Soluble receptor of interleukin-6, and C reactive protein
Zinc
C reactive protein
interleukin 6
interleukin 6 receptor
zinc
abdominal surgery
acute pancreatitis
adult
aged
article
clinical article
critically ill patient
diet supplementation
enzyme linked immunosorbent assay
female
human
ileus
inflammation
intestine cancer
intestine fistula
male
total parenteral nutrition
Adult
Aged
C-Reactive Protein
Critical Illness
Female
Humans
Interleukin-6
Male
Middle Aged
Parenteral Nutrition, Total
Receptors, Interleukin-6
Zinc
Fistula
spellingShingle Critically ill patients with parenteral nutrition
Interleukin-6
Soluble receptor of interleukin-6, and C reactive protein
Zinc
C reactive protein
interleukin 6
interleukin 6 receptor
zinc
abdominal surgery
acute pancreatitis
adult
aged
article
clinical article
critically ill patient
diet supplementation
enzyme linked immunosorbent assay
female
human
ileus
inflammation
intestine cancer
intestine fistula
male
total parenteral nutrition
Adult
Aged
C-Reactive Protein
Critical Illness
Female
Humans
Interleukin-6
Male
Middle Aged
Parenteral Nutrition, Total
Receptors, Interleukin-6
Zinc
Fistula
Menéndez, A.Ma.
De Portela, Ma.L.P.M.
Weisstaub, A.
Montemerlo, H.
Guidoni, Ma.E.
Rusí, F.
Zeni, S.
Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
topic_facet Critically ill patients with parenteral nutrition
Interleukin-6
Soluble receptor of interleukin-6, and C reactive protein
Zinc
C reactive protein
interleukin 6
interleukin 6 receptor
zinc
abdominal surgery
acute pancreatitis
adult
aged
article
clinical article
critically ill patient
diet supplementation
enzyme linked immunosorbent assay
female
human
ileus
inflammation
intestine cancer
intestine fistula
male
total parenteral nutrition
Adult
Aged
C-Reactive Protein
Critical Illness
Female
Humans
Interleukin-6
Male
Middle Aged
Parenteral Nutrition, Total
Receptors, Interleukin-6
Zinc
Fistula
description Objectives: To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. Methods: 17 patients, receiving TPN as a consequence of acute pancreatitis (n = 4) or after a major abdominal surgery due to intestinal cancer (n = 7), intestinal fístula (n = 3), intestinal obstruction (n = 2) or intestinal íleus (n = 1) were studied. At the beginning (To) and at the end of the TPN administration (6-21days) serum IL-6 and IL-6 sR were determined by ELISA; C-RP ultrasensitive (C-RP us) by inmunoturbidimetric method; Zn was determined in TPN and in plasma by Atomic Absorption Spectrometry. Characteristics of the patients were (mean ± SD and ranges): age: 60.6 ± 11.7 (37-77) years; BMI (kg/m2): 26.0 ± 3.4 (19.9-34.0). Results: The results (mean ± standard deviation and ranges) were: Zn provided by TPN (mg/d): 6.1 ± 2.0 (range 2.8 to 10.8). Biochemical levels were, at To and Tf, respectively: (mean±SD and ranges) were at To y Tf, respectively: Zn Pl (?g/dl): 104 ± 46 (35-177); 120 ± 55 (52-229); IL-6 (pg/mL) 93 ± 74 (10-262); 117 ± 180 (7-761); IL6sR (pg/mL): 1,012 ± 322 (589-1855); 1,269 ± 451 (631-2195); C-RP us (mg/L): 71 ± 63 (2-196); 65 ± 43 (0-137). There was no correlation between variations of IL6, IL6sR, C-RP, PlZn levels and the daily amount of Zn administered in the TPN mixtures. Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased Conclusions: the range of 2.8 to 10.8 mg/d of Zn administered in TPN mixtures did not exacerbate the inflammatory response.
format JOUR
author Menéndez, A.Ma.
De Portela, Ma.L.P.M.
Weisstaub, A.
Montemerlo, H.
Guidoni, Ma.E.
Rusí, F.
Zeni, S.
author_facet Menéndez, A.Ma.
De Portela, Ma.L.P.M.
Weisstaub, A.
Montemerlo, H.
Guidoni, Ma.E.
Rusí, F.
Zeni, S.
author_sort Menéndez, A.Ma.
title Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
title_short Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
title_full Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
title_fullStr Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
title_full_unstemmed Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
title_sort influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive c protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
url http://hdl.handle.net/20.500.12110/paper_02121611_v24_n3_p340_Menendez
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