Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities

In this work, a series of hybrid compounds were tested as antiparasitic substances. These hybrids were prepared from bile acids and a series of antiparasitic Cinchona alkaloids by the formation of a covalent C-C bond via a decarboxylative Barton-Zard reaction between the two entities. The bile acids...

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Detalles Bibliográficos
Autores principales: Leverrier, A., Bero, J., Cabrera, J., Frédérich, M., Quetin-Leclercq, J., Palermo, J.A.
Formato: JOUR
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Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02235234_v100_n1_p10_Leverrier
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