Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities

In this work, a series of hybrid compounds were tested as antiparasitic substances. These hybrids were prepared from bile acids and a series of antiparasitic Cinchona alkaloids by the formation of a covalent C-C bond via a decarboxylative Barton-Zard reaction between the two entities. The bile acids...

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Detalles Bibliográficos
Autores principales: Leverrier, A., Bero, J., Cabrera, J., Frédérich, M., Quetin-Leclercq, J., Palermo, J.A.
Formato: JOUR
Materias:
Antiparasitic activity
Barton-Zard reaction
Bile acids
Cinchona alkaloids
Hybrids
artemisinin
bile acid
camptothecin
chloroquine
Cinchona alkaloid
suramin
antimalarial agent
antitrypanosomal agent
antimalarial activity
antiplasmodial activity
antiprotozoal activity
antitrypanosomal activity
Article
controlled study
drug bioavailability
drug cytotoxicity
drug synthesis
fibroblast
heteronuclear multiple bond correlation
human
human cell
hybrid
IC50
in vitro study
lipophilicity
nonhuman
nuclear magnetic resonance spectroscopy
Plasmodium falciparum
structure activity relation
Trypanosoma brucei
chemistry
conformation
dose response
drug effects
drug sensitivity
synthesis
Trypanosoma brucei brucei
Antimalarials
Bile Acids and Salts
Cinchona Alkaloids
Dose-Response Relationship, Drug
Molecular Conformation
Parasitic Sensitivity Tests
Structure-Activity Relationship
Trypanocidal Agents
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02235234_v100_n1_p10_Leverrier
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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