Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing

Here we investigate the promoter control of alternative splicing by studying two transcriptional activators on templates under replicating conditions. SV40 large T-antigen (T-Ag) activates template replication only 2-fold but transcription 25-fold. T-Ag-mediated replication, reported to inhibit RNA...

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Detalles Bibliográficos
Autores principales: Kadener, S., Cramer, P., Nogués, G., Cazalla, D., De La Mata, M., Fededa, J.P., Werbajh, S.E., Srebrow, A., Kornblihtt, A.R.
Formato: JOUR
Materias:
Alternative splicing
SV40 T-Ag
VP16
etoposide
fibronectin
RNA polymerase II
virus large T antigen
alternative RNA splicing
animal cell
article
cell transformation
controlled study
DNA replication
DNA template
exon
human
human cell
Human immunodeficiency virus
nonhuman
priority journal
promoter region
Simian virus 40
structural gene
transcription initiation
transcription regulation
Alternative Splicing
Animals
Antigens, Polyomavirus Transforming
Carcinoma, Hepatocellular
Cercopithecus aethiops
COS Cells
DNA Replication
DNA, Recombinant
Exons
Fibronectins
Herpes Simplex Virus Protein Vmw65
Humans
In Situ Hybridization
Liver Neoplasms
Promoter Regions (Genetics)
Recombinant Fusion Proteins
Reverse Transcriptase Polymerase Chain Reaction
RNA Polymerase II
RNA, Messenger
Templates, Genetic
Transcription, Genetic
Transfection
Animalia
DNA viruses
RNA viruses
Simiae
Simian virus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02614189_v20_n20_p5759_Kadener
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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