Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation

Alternative splicing contributes to cell type-specific transcriptomes. Here, we show that changes in intragenic chromatin marks affect NCAM (neural cell adhesion molecule) exon 18 (E18) alternative splicing during neuronal differentiation. An increase in the repressive marks H3K9me2 and H3K27me3 alo...

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Detalles Bibliográficos
Autores principales: Schor, I.E., Fiszbein, A., Petrillo, E., Kornblihtt, A.R.
Formato: JOUR
Materias:
Alternative splicing
Chromatin
Differentiation
Pol II elongation
azacitidine
messenger RNA
n (1 benzyl 4 piperidinyl) 2 (hexahydro 4 methyl 1h 1,4 diazepin 1 yl) 6,7 dimethoxy 4 quinazolinamine
nerve cell adhesion molecule
small interfering RNA
acetylation
alternative RNA splicing
animal cell
article
depolarization
DNA methylation
epigenetics
heterochromatin
mouse
nerve cell differentiation
nonhuman
priority journal
upregulation
Alternative Splicing
Animals
Azacitidine
Azepines
Cell Differentiation
Cell Line, Tumor
Chromatin Immunoprecipitation
DNA Methylation
DNA Primers
Epigenesis, Genetic
Exons
Mice
Neural Cell Adhesion Molecules
Neurons
Quinazolines
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA, Small Interfering
Sequence Analysis, DNA
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02614189_v32_n16_p2264_Schor
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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