PyNTTTTGT prototype oligonucleotide IMT504 is a potent adjuvant for the recombinant Hepatitis B vaccine that enhances the Th1 response

PyNTTTTGT oligodeoxinucleotides (ODNs) cause activation, proliferation and immunoglobulin secretion on B cells, and the expression of co-stimulatory molecules on plasmacytoid dendritic cells of primates. It has now been discovered that these ODNs are also active on rat cells. This fact allowed us to...

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Autores principales: Elias, F., Flo, J., Rodriguez, J.M., De Nichilo, A., Lopez, R.A., Zorzopulos, J., Nagle, C., Lahoz, M., Montaner, A.
Formato: JOUR
Materias:
Immunostimulatory oligonucleotide
Th1 answer
Vaccine adjuvant
aluminum potassium sulfate
gamma interferon
hepatitis B antigen
immunoglobulin G2b
immunological adjuvant
imt 504
oligonucleotide
recombinant hepatitis B vaccine
unclassified drug
animal cell
animal experiment
animal tissue
antibody production
antibody titer
antigen antibody reaction
article
B lymphocyte
bioassay
cell secretion
cellular immunity
controlled study
cytokine release
drug potency
female
Hepatitis B virus
immune response
immunoglobulin production
immunostimulation
in vitro study
monkey
nonhuman
physical chemistry
priority journal
rat
Th1 cell
Th2 cell
vaccination
vaccine production
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0264410X_v23_n27_p3597_Elias
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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