An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation

Mitogen-activated protein kinase (MAPK) pathways constitute key regulatory elements linking extracellular stimuli to nuclear gene expression. Immediate-early responsive genes (IEGs) of the activator protein 1 (AP-1) family, such as fos, achieve peak expression levels shortly after cells are stimulat...

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Detalles Bibliográficos
Autores principales: Degese, M.S., Tanos, T., Naipauer, J., Gingerich, T., Chiappe, D., Echeverria, P., LaMarre, J., Gutkind, J.S., Coso, O.A.
Formato: JOUR
Materias:
AUBPs.
C-fos
P38 MAPKs
Stability of mRNAs
acidic leucine rich nuclear phosphoprotein 32 family member B
AU rich binding protein
binding protein
far upstream element binding protein 2
Hu antigen
Hu antigen R
messenger RNA
mitogen activated protein kinase p38
phosphoprotein
phosphoprotein phosphatase 2
protein c fos
unclassified drug
3' untranslated region
ELAVL1 protein, human
hybrid protein
KHSRP protein, human
KSRP protein, mouse
mitogenic agent
protein kinase inhibitor
RNA binding protein
transactivator protein
Article
cell proliferation
controlled study
embryo
enzyme activity
epithelium cell
fibroblast
gene overexpression
human
human cell
mitogenesis
priority journal
protein function
protein phosphorylation
protein protein interaction
protein RNA binding
RNA stability
3T3 cell line
animal
chemistry
comparative study
drug effects
genetics
HEK293 cell line
HeLa cell line
metabolism
mouse
mutation
phosphorylation
protein processing
signal transduction
3' Untranslated Regions
Animals
Cell Proliferation
HEK293 Cells
HeLa Cells
Hu Paraneoplastic Encephalomyelitis Antigens
Humans
MAP Kinase Signaling System
Mice
Mitogens
Mutation
NIH 3T3 Cells
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Protein Kinase Inhibitors
Protein Processing, Post-Translational
Proto-Oncogene Proteins c-fos
Recombinant Fusion Proteins
RNA Stability
RNA, Messenger
RNA-Binding Proteins
Trans-Activators
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02646021_v467_n1_p77_Degese
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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