Effect of dietary fish oil on mouse ocular Herpes Simplex type I infection

Balb/c mice fed a diet containing 20% fish oil developed herpes stromal keratitis earlier and with more severe lesions than control group. Peritoneal macrophages oxidative metabolism and intrinsic antiviral activity are not modified by diet manipulation but nitric oxide production was significantly...

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Detalles Bibliográficos
Autores principales: Courrèges, M.Cecilia, Benencia, F., Monserrat, A.J.
Formato: JOUR
Materias:
Fish oil
Herpes Simplex type 1
Immune response
Lymphocytes
Macrophages
Ocular keratitis
corn oil
fish oil
animal experiment
animal model
article
controlled study
delayed hypersensitivity
diet
disease association
disease course
disease severity
herpes simplex keratitis
immune response
lymphocyte proliferation
mouse
nonhuman
priority journal
T lymphocyte
Herpes
Human herpesvirus 1
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02715317_v21_n1-2_p229_Courreges
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Balb/c mice fed a diet containing 20% fish oil developed herpes stromal keratitis earlier and with more severe lesions than control group. Peritoneal macrophages oxidative metabolism and intrinsic antiviral activity are not modified by diet manipulation but nitric oxide production was significantly impaired. On the contrary, splenic lymphocytes proliferation stimulated "ex vivo" by heat inactivated HSV-1 is significantly increased as well as delayed type hypersensitivity. So, taking into account that herpes stromal keratitis is mediated by T cells, the effect of diet over these cells could be responsible for the observed exacerbation of the disease. © 2001 Elsevier Science Inc.

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