Repeated methamphetamine and modafinil induce differential cognitive effects and specific histone acetylation and DNA methylation profiles in the mouse medial prefrontal cortex

Methamphetamine (METH) and modafinil are psychostimulants with different long-term cognitive profiles: METH is addictive and leads to cognitive decline, whereas modafinil has little abuse liability and is a cognitive enhancer. Increasing evidence implicates epigenetic mechanisms of gene regulation b...

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Detalles Bibliográficos
Autores principales: González, B., Jayanthi, S., Gomez, N., Torres, O.V., Sosa, M.H., Bernardi, A., Urbano, F.J., García-Rill, E., Cadet, J.-L., Bisagno, V.
Formato: JOUR
Materias:
Cognition
DNA methylation
Histone acetylation
Methamphetamine
Modafinil
Prefrontal cortex
DNA
histone
messenger RNA
methamphetamine
modafinil
neurotransmitter
central stimulant agent
Adra1a gene
Adra1b gene
animal experiment
animal tissue
arousal
Article
cognition
controlled study
Drd1 gene
Drd2 gene
epigenetics
executive function
gene
gene expression
genetic transcription
Gria1 gene
Grin1 gene
Hcrtr1 gene
Hcrtr2 gene
histone acetylation
Hrh1 gene
Hrh3 gene
locomotion
medial prefrontal cortex
mouse
nonhuman
promoter region
recognition
reverse transcription polymerase chain reaction
wakefulness
acetylation
animal
C57BL mouse
chemically induced
drug effect
male
memory disorder
metabolism
physiology
prefrontal cortex
Acetylation
Animals
Central Nervous System Stimulants
DNA Methylation
Histones
Male
Memory Disorders
Mice, Inbred C57BL
Prefrontal Cortex
Recognition (Psychology)
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02785846_v82_n_p1_Gonzalez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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