Multiple sites of tumorigenesis in transgenic mice overproducing hCG

We have produced transgenic (TG) mice expressing under the ubiquitin C promoter either the glycoprotein hormone common α-subunit (Cα) or human chorionic gonadotropin (hCG) β-subunit. Cα overexpression alone had no phenotypic effect, but the hCGβ expressing females, presenting with moderately elevate...

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Detalles Bibliográficos
Autores principales: Huhtaniemi, I., Rulli, S., Ahtiainen, P., Poutanen, M.
Formato: JOUR
Materias:
Choriongonadotropin
Leydig cell adenoma
Luteoma
Mammary tumours
Ovarian tumours
Pituitary tumours
Prolactinoma
Teratoma
Transgenic mice
chorionic gonadotropin
luteinizing hormone
prolactin
protein subunit
sex hormone
ubiquitin C
adulthood
alpha chain
blood level
breast carcinoma
breast tumor
cancer localization
carcinogenesis
cell type
conference paper
gene overexpression
germ cell tumor
gonadectomy
hormone release
human
hyperplasia
hypophysis
hypophysis tumor
Leydig cell
luteinization
luteoma
mammary gland
nonhuman
ovary teratoma
ovary tumor
pathophysiology
perinatal period
phenotype
priority journal
prolactinoma
protein expression
seminiferous tubule epithelium
somatic cell
transgene
transgenic mouse
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03037207_v234_n1-2_p117_Huhtaniemi
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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