Tumor-specific MAGE proteins as regulators of p53 function

Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms cont...

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Detalles Bibliográficos
Autores principales: Ladelfa, M.F., Peche, L.Y., Toledo, M.F., Laiseca, J.E., Schneider, C., Monte, M.
Formato: JOUR
Materias:
Anticancer therapies
MAGE
P53
Transcriptional inhibition
etoposide
histone deacetylase inhibitor
melanoma antigen 1
protein Bax
protein p53
survivin
trichostatin A
carcinogenesis
cell proliferation
drug cytotoxicity
drug targeting
gene expression regulation
head and neck carcinoma
human
melanoma
multiple myeloma
nonhuman
priority journal
protein expression
protein family
protein function
sequence homology
short survey
Animals
Cell Growth Processes
Humans
Melanoma
Melanoma-Specific Antigens
Tumor Suppressor Protein p53
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03043835_v325_n1_p11_Ladelfa
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. © 2012 Elsevier Ireland Ltd.

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