Inhibition of the PI3K/Akt pathway by Ly294002 does not prevent establishment of persistent Junín virus infection in Vero cells

In previous work, we demonstrated that the arenavirus Junín virus (JUNV) is able to activate Akt by means of the phosphatidylinositol-3-kinase (PI3K) survival pathway during virus entry. This work extends our study, emphasizing the relevance of this pathway in the establishment and maintenance of pe...

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Detalles Bibliográficos
Autores principales: Linero, F.N., Fernández Bell-Fano, P.M., Cuervo, E., Castilla, V., Scolaro, L.A.
Formato: JOUR
Materias:
Junín virus
LY294002
Persistence
PI3K/AKT
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
chromone derivative
enzyme inhibitor
morpholine derivative
phosphatidylinositol 3 kinase
protein kinase B
virus protein
animal
antagonists and inhibitors
apoptosis
biosynthesis
cell line
Chlorocebus aethiops
drug effects
growth, development and aging
Hemorrhagic Fever, American
Junin virus
physiology
Vero cell line
virology
virus entry
virus replication
Animals
Apoptosis
Cell Line
Cercopithecus aethiops
Chromones
Enzyme Inhibitors
Morpholines
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
Vero Cells
Viral Proteins
Virus Internalization
Virus Replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03048608_v160_n2_p469_Linero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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