Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation

1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. δ-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was als...

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Detalles Bibliográficos
Autores principales:	Buzaleh, A.M., Vazquez, E.S., Nuñez, G., Batlle, A.M.D.C.
Formato:	JOUR
Materias:	Chronic anesthesia Drug-metabolizing enzyme system Enflurane Heme metabolism Isoflurane 5 aminolevulinate synthase beta glucuronidase cytochrome p450 enflurane glutathione transferase isoflurane phenobarbital sulfatase tryptophan 2,3 dioxygenase anesthesia animal experiment article drug metabolism enzyme activity male mouse nonhuman priority journal 5-Aminolevulinate Synthetase Aminolevulinic Acid Anesthetics, Inhalation Animals Cytochrome P-450 Enzyme System Heme Hypnotics and Sedatives Liver Male Mice Phenobarbital Porphobilinogen Porphyrins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03063623_v28_n4_p577_Buzaleh
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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